人胃癌裸鼠原位移植模型的生物学行为研究
胃肿瘤;肿瘤转移;肿瘤移植;疾病模型，动物,项目负责人,Correspondenceto,Biologicalbehavioroforthotopicimplantationmodelofhumangastriccarcinomainnudemice,Abstract,,AIM,METHODS,RESULTS,CONCLUSION,Subjectheading
广东医学院病理教研室 广东省湛江市 524023罗明华，女，1971-12-02生，江西省信丰县人，汉族. 1994年华北煤炭医学院临床医学系毕业1997年广东医学院肿瘤病理学硕士生毕业，现为广东省惠州市中心人民医院病理科临床病理医生，发表论文1篇.
项目负责人 罗明华，524023，广东医学院病理教研室，广东省惠州市鹅岭北路41号.
Correspondence to Ming-Hua Luo, Department of Pathology, Guangdong Medical College, 41 Eling Beilu, Zhanjiang 524023, China
Tel. +86·752·2127569(O)
收稿日期 1998-03-08
Biological behavior of orthotopic implantation model of human gastric carcinoma in nude mice
Ming-Hua Luo, Wei-Ping Tang, Pei-Gen Huang, Qiong-Zhen Cai, Fei-Hong Li and Mei-Ying Mo
Department of Pathology, Guangdong Medical College, Zhanjiang 524023, China
Abstract
AIM To establish an orthotopic model of human gastric carcinoma in the stomach wall of nude mice, and compare with its ectopic implantation counterpart in the subcutaneous tissues in oder to investigate whether the microenvironment of the host organ influenced the biological behavior such as invasion and metastasis of the carcinoma cells.
METHODS The human gastric carcinoma cell line MGc-803 and its clonal line C11 were inoculated into the stomach wall and the subcutaneous tissues of nude mice respectively. The tumor formation rate, the growth rate, the mode of growth, the invasion and metastatic behavior of the orthotopic and ectopic xenografts were investigated and compared. The specimens from the xenografts was cultured in vitro, and the cell proliferation ability was determined. ......
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