Circulatingsolubleintercellula

Circulating soluble intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in patients with gastric cancer

http://www.100md.com 1998年12月15日《世界华人消化杂志》 1998年第12期

Circulatingsolubleintercellularadhesionmolecule-1andvascularcelladhesionmolecule-1inpatientswithgastriccancer,Correspondenceto,Abstract,,AIM,METHODS,RESULTS,CONCLUSION,Subjectheadings,INTRODUCTION,MATERIALSANDMETHODS,Methods,Statisticalanalysis,RESUL

     Shanghai First Peoples Hospital, Shanghai 200080, China

    Dr. Yu-Fa Wang, male, born on 1963-07-31 in Shanghai, graduated from Shanghai Medical University in 1987 and got master degree from Shanghai Institute of Immunology, Shanghai Second Medical University in 1990, now associated professor,having 20 papers published.

    Correspondence to Dr. WANG Yu-Fa, Central Research Laboratory, Shanghai First Peoples Hospital,85 Wujin Road, Shanghai 200080, China

    Tel. +86·21·63240090 ext 4602

    Reveived 1998-07-15

    Abstract

    AIM To elucidate the biological and clinical significance of sICAM-1 and sVCAM-1 in patients with gastric cancer.

    METHODS The serum levels of soluble ICAM-1 and VCAM-1 were measured with sandwith enzyme immunoassay.

    RESULTS In gastric cancer patients, soluble ICAM-1 and VCAM-1 concentrations were significantly elevated in comparision with those of healthy subjects (289.23μg/L±32.69μg/Lvs 190.44μ/L±35.92μg/L，1430.88μg/L±421.71μg/L vs 727.24μg/L±157.68μg/L, respectively, P<0.01). The increment in serum sICAM-1 and sVCAM-1 concentrations correlated well with the staging of gastric cancer. The serum levels of sICAM-1 and sVCAM-1 in patients of Ⅲ-Ⅳ stages were higher than those of Ⅰ-Ⅱ stages (346.60μg/L±92.10μg/Lvs257.54μg/L±32.77μg/L, 1800.60μg/L±510.76μg/L vs 1262.81μg/L±236.73μg/L). The levels of sICAM-1 and sVCAM-1 were correlated significantly (r=0.49 ......

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