红霉素、维拉帕米及低分子肝素对术后腹腔粘连的预防作用
腹腔粘连预防和控制;手术后并发症;疾病模型,动物;红霉素;维拉帕米;肝素,项目负责人,Correspondenceto,Effectsoferythromycin,verapamilandlowmolecularweightheparinonpostoperativeperitonealadhesioninrats,,Abstr
山西医科大学第一医院普外科 山西省太原市 030001陈玺华，男，1962-05-23生，内蒙古卓资县人，汉族. 1981年山西省大同医学专科学校毕业，1997年山西医科大学硕士毕业，主治医师，主要从事消化系统疾病的病理生理及临床研究，发表论文5篇.
项目负责人 陈玺华，030001，山西医科大学第一医院普外科，山西省太原市解放南路85号.
Correspondence to Xi-Hua Chen, Department of General Surgery, the First Hospital, Shanxi Medical University,Taiyuan 030001, Shanxi Province, China
Tel. +86·351·6126736 Fax. +86·351·6126736
收稿日期 1998-07-06
Effects of erythromycin, verapamil and low molecular weight heparin on postoperative peritoneal adhesion in rats
Xi-Hua Chen, Min-Sheng Bao, Zheng-Zhong Li, Yue-Ming Zhang, Yu-Lan Zhang and Ping Jian
Department of General Surgery, the First Hospital, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
Abstract
AIM To investigate the effect of erythromycin (Ery), verapamil (VRP) and low molecular weight heparin (LMWH) on postoperative peritoneal adhesions.
METHODS The adhesions were induced at laparotomy by two different operative models. The 90 rats were randomly divided into 5 groups: ①control; ②LMWH (300IU/kg ip); ③Ery (8mg/kg sc); ④VRP (200μg/kg ip); and ⑤combined (LMWH+Ery+VRP). All animals were reexplored at the 9th day postoperatively for evaluation of adhesion formation. ......
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