消化系癌血清微量元素与T细胞亚群相关性研究的价值
微量元素;T细胞亚群;消化系统肿瘤,项目负责人,CorrelationbetweentraceelementsandTcellsubsetsindigestivesystemcanceranditsclinicalsignificance,Abstract,AIM,METHODS,RESULTS,CONCLUSION,Subjectheadings,摘要,目的
山西省肿瘤研究所病因室 山西省太原市 030013荆洁线，女，1964-12-23生，山西省运城人，汉族. 1986年山西大学化学系毕业，助理研究员，主要从事肿瘤病因研究，发表论文13篇.
项目负责人 荆洁线，030013，山西省肿瘤研究所病因室，山西省太原市职工新村3号.Tel. +86·351·4425911 Ext.481
收稿日期 1998-08-17
Correlation between trace elements and T cell subsets in digestive system cancer and its clinical significance
Jie-Xian Jing, Cun-Zhi Han, Xian-Wen Zhao, Jin-Gang Guo and Li-Fang Wang
Abstract
AIM To study the correlation between trace elements (TE) and T cell subjects (CD+T) in digestive system cancer and its clinical significance.
METHODS Serum zinc, copper, iron, manganese, calcium levels were determined in 312 patients with digestive system cancer and 100 healthy subjects by atomic absorption spectrophotometry. The T cell subjects were measured in 48 patients and healthy subjects by indirect immunofluorescence method.
RESULTS In patients with digestive system cancer serum copper, copper/zinc ratio, CD8+ were significantly higher and zinc, calcium
CD3+, CD4+, CD4+/CD8+ were significantly lower than that in healthy subject respectively (P<0.01). Patients in stage Ⅲ-Ⅳ and metastatic cancer had much higher copper level, copper/zinc ratio, CD8+ and had much lower zinc, CD4+, CD4+/CD8+ than patients in stage Ⅰ-Ⅱ respectively (P<0.05-P<0.01). Linear correlation analysis showed that serum copper, Cu/Zn ratio had negative correlation with CD4+ and CD4+/CD8+ and zinc had positive correlation with CD4+/CD8+ respectively (P<0.05-P<0.01). Multi-variable logistic regression analysis showed that serum copper, Cu/Zn ratio elevation might be the dangerous factors and serum Zinc, calcium might have a certain inhabition on digestive system cancer. ......
您现在查看是摘要页，全文长 13972 字符。