肝病患者内毒素血症的临床意义
肝病;内毒素血症;纤维连接蛋白;肿瘤坏死因子,项目负责人,Correspondenceto,Clinicalsignificanceofendotoxemiainliverdiseases,Abstract,AIM,METHODS,RESULTS,CONCLUSION,Subjectheadings,摘要,目的,方法,结果,结论,主题词,0引言,1
山西医科大学肝病研究所 山西省太原市 030001赵龙凤，女，1954-03-26生，山西省忻州市人，汉族. 1979年山西医科大学毕业，教授，主要从事肝病的基础与临床研究.
项目负责人 赵龙凤，030001，山西省太原市新建南路86号，山西医科大学肝病研究所.
Correspondence to Long-Feng Zhao, Institute for Liver Diseases, Shanxi Medical University, 86 Xinjian Nanlu,Taiyuan 030001, Shanxi Province, China
收稿日期 1998-09-01 接收日期 1999-01-18
Clinical significance of endotoxemia in liver diseases
Long-Feng Zhao and De-Wu Han
Institute for Liver Diseases, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
Abstract
AIM To explore the occurrence and clinical significance of endotoxemia in liver diseases.
METHODS Plasma endotoxin (ET) level was measured by using chromogenic limulus amebocyte lysate (LAL) assay, TNFα with radioimmunoassay (RIA), fibronectin (Fn) with single immunity diffusion and alanine aminotransferase (ALT) activity with rate assay in 320 patients with acute, chronic hepatitis, liver cirrhosis or severe hepatitis.
RESULTS Plasma ET, ALT and TNF α contents in patients with liver diseases were significantly higher than that of controls, whereas Fn contents in patients with liver cirrhosis, severe hepatitis were significantly lower than that of controls respectively. The incidence rates of endotoxemia in patients with severe hepatitis, liver cirrhosis, chronic hepatitis, acute hepatitis were 93.3% ......
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