树鼠句传代感染HDV后肝脏内抗原表达及病理变化
肝炎,丁型;抗原,病毒;肝,病理学,项目负责人,Correspondenceto,ExpressionofintrahepaticHDAgandpathologicalchangesfollowingserialpassagesofHDVinfectionintupaiae,Abstract,ATM,METHODS,RESULTS,CONCLUSION,Subjectheadi
第三军医大学西南医院全军传染病中心 重庆市 400038李奇芬，女，1932-12- 生，江苏省南京市人，汉族. 1957年毕业于北京协和医学院(8年制)，现任教授，主任医师，第三军医大学校专家组成员，从事传染病主要是病毒性肝炎的医、教、研工作，发表论文80篇.
项目负责人 李奇芬，400038，重庆市，第三军医大学西南医院全军传染病中心.
Correspondence to Qi-Fen Li, Infectious Diseases Center, Southwest Hospital, Third Military Medical University,Chongqing 400038, China
收稿日期 1998-09-23
Expression of intrahepatic HDAg and pathological changes following serial passages of HDV infection in tupaiae
Qi-Fen Li, Qing Mao, Chun-Qing Wu, Wei-Qiang Wu, Hong Wang and Hong-Wen Li
Infectious Diseases Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
Abstract
ATM To observe the intrahepatic HDAg and pathological changes following artificial serial passages of HDV infection in tupaiae.
METHODS All of the experimental animals used in this study are wild tupaiae. In the serial passages, the first tupaia was inoculated with human HDV positive serum, 4 tupaiae of the second passage with 0.4mL of the serum of the first passage, and the 5 tupaiae of the third with 0.4mL of the 2nd passage. All of the 9 tupaiae were inoculated with human HBV positive serum 3-5 weeks before HDV injection. Blood samples and liver tissue specimens were collected once a week for at least 6 weeks. Pathological changes (H.E. stain), intrahepatic HDAg (S-P method) and HDV RNA (hybridization in situ) were studied. ......
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