丹酚酸A抗过氧化鼠肝损伤的作用
丹酚酸A;肝损伤;脂质过氧化,上海市教委曙光计划资助课题，,No.96SG26.,项目负责人,SupportedbyShuguangProgramProjectofShanghaiEducationalCommittee,No.96SG26.,,Correspondenceto,Anti-peroxidationeffectsof,salvia-nolicacidAonCCl4ind
上海中医药大学肝病研究所 上海市 200032刘成，男，1939-03-03生，上海市人，汉族. 1962年上海医科大学医疗系毕业，教授，研究员，博士生导师. 主要从事中医药防治慢性肝病的临床与实验研究，发表论文80篇，获国家中医药管理局与上海市科技进步成果奖8项.
上海市教委曙光计划资助课题，No.96SG26.
项目负责人 刘成，200032，上海市零陵路530号，上海中医药大学肝病研究所.
Supported by Shuguang Program Project of Shanghai Educational Committee, No.96SG26.
Correspondence to Cheng Liu, Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine,530 Lingling Road, Shanghai 200032, China
Tel/Fax. +86·21·64036889
Email. liuliver@online. sh. cn
收稿日期 1999-01-09 接收日期 1999-03-14
Anti-peroxidation effects of salvia-nolic acid A on CCl4 induced liver injury
Cheng Liu, Yi-Yang Hu, Run-Ping Wang, Cheng-Hai Liu and Ping Liu
Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Abstract
AIM To investigate the anti-peroxidation effects of salvianolic acid A(SA-A) on liver injury.
METHODS Liver injury models were induced by carbon tetrachloride (CCl4) in rats in vivo, and treated with Salvianolic acid A. Histopathologic changes of the liver samples, serum albumin contents, serum alanine aminotransferase (ALT) and asparate aminotransferase (AST) activities, malondialdehyde (MDA) contents in the livers were observed. The primarily cultured hepatocytes were injured by CCl4 gas in vitro, and incubated with salvianolic acid A. Influence of the drug on the activities of ALT, AST and GSH-PX, and on contents of MDA and glutathione (GSH) were observed. ......
您现在查看是摘要页，全文长 11507 字符。