生长抑素类似物对急性胰腺炎时胰腺细胞凋亡的作用机制
胰腺炎;细胞凋亡;生长抑素类似物;bax基因;p53基因,项目负责人,Correspondenceto,Effectsandmechanismsofsomatostatinanaloguesonapoptosisofpancreaticacinarcells,inacutepancreatitisinmice,,Abstract,AIM,METHODS
上海第二医科大学附属瑞金医院消化内科 上海市 200025龚自华，男，1974-12-07生，安徽巢湖市人，汉族. 1997年蚌埠医学院临床医学系本科毕业，医学学士，现上海第二医科大学附属瑞金医院消化内科在读硕士研究生，主要从事胰腺疾病的临床和基础研究，发表论文3篇，参与一本专著的编写.
项目负责人 龚自华，200025，上海市，上海第二医科大学附属瑞金医院消化内科.
Correspondence to Zi-Hua Gong, Department of Gastroenterology, Ruijin Hospital, Shanghai Second Medical University,Shanghai 200025, China
Tel. +86·21·64370045 Ext. 665242，Fax. +86·21·64333548
收稿日期 1999-07-11
Effects and mechanisms of somatostatin analogues on apoptosis of pancreatic acinar cells
in acute pancreatitis in mice
Zi-Hua Gong, Yao-Zong Yuan, Kai-Xian Lou, Shui-Ping Tu, Zu-Kang Zhai and Jia-Yu Xu
Department of Gastroenterology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
Abstract
AIM To investigate the effects of somatostatin analogues on apoptosis of pancreatic acinar cells and apoptosis-regulated gene bax and p53 in treating acute pancreatitis in mice.
METHODS In caerulein-induced pancreatitis with or without treatment of somatostatin analogues in CD-1 mice, apoptosis of pancreatic acinar cells was detected by TUNEL method, and the expression of apoptosis-regulated gene bax and p53 was determined by SP immunohistochemical technique. ......
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