宫入菌对急性坏死性胰腺炎大鼠肠道细菌移居的作用
胰腺炎,急性;肠道细菌移居;宫入菌,部分系上海市科学技术委员会科技启明星计划资助课题，,No.99QB14009,项目负责人,Correspondenceto,Effectsofclostridiumbutyricumonbacterialtranslocationinratswithacutenecrotizingp
上海市第一人民医院消化科 消化疾病研究室 上海市 200080吴恺，男，1968-08-28生，浙江省湖洲市人，汉族. 1990年上海医科大学检验系毕业，现为上海市第一人民医院消化科、消化疾病研究室主管技师.
部分系上海市科学技术委员会科技启明星计划资助课题，No.99QB14009
项目负责人 王兴鹏，200080，上海市，上海市第一人民医院消化科、消化疾病研究室.
Department of Gastroenterology, Laboratory for GI Diseases, Shanghai First People＇s Hospital, Shanghai 200080, China
Correspondence to Xing-Peng Wang, Department of Gastroenterology, Shanghai First People＇s Hospital, Shanghai 200080, China
Tel. 0086-21-63240090, Fax. 0086-21-63240825
Email. xpwcn@public7.sta.net.cn
收稿日期 2000-04-24 接收日期 2000-05-22
Effects of clostridium butyricum on bacterial translocation in rats with acute necrotizing pancreatitis
Kai Wu, Bing-Xian Wang and Xing-Peng Wang
Abstract
AIM To evaluate the effects of clostridium butyricum on bacterial translocation in rats with acute necrotizing pancreatitis (ANP).
METHODS Twenty-seven SD rats were assigned to three groups randomly, including sham-operation, ANP without treatment and ANP treated with clostridium butyricum. ANP model was made by injection of 5% sodium tarucholate into the bilio-pancreatic duct. Pathological changes in pancreas and ileum were studied. Serum lipase and amylase activities and serum endotoxin were determined. Bacterial culture in pancreas, liver, spleen and mesenteric lymph nodes (MLN) were made. Changes in intestinal bacterial flora and sIgA were investigated. ......
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