四氯化碳诱导鼠肝血管生成因子免疫组织化学观察
肝疾病,化学诱导;四氯化碳;血管生成因子;免疫组织化学;肝硬化,项目负责人,Correspondenceto,ImmunohistochemicalstudyonhepaticvascularformingfactorsinliverfibrosisincucedbyCCl4inrats,Abstract,AIM,METHODS,RES
中国人民解放军123医院肝病中心 安徽省蚌埠市 233015严家春，男，1941-06-26生，安徽省定远县人，汉族. 1972年第七军医大学医资班毕业，主任医师，教授，主要从事肝脏的病理研究，发表论文126篇. 获军队科技进步二、三、四等奖14项.
项目负责人 严家春，233015，安徽省蚌埠市，中国人民解放军123医院肝病中心.
Centre of Liver Diseases of Chinese PLA 123rd Hospital, Bengbu 233015, Anhui Province, China
Correspondence to Jia-Chun Yan, Centre of Liver Diseases of Chinese PLA 123rd Hospital, Bengbu 233015,Anhui Province, China
Tel. 0086-552-4125701(H)
Received 2000-06-22 Accepted 2000-06-29
Immunohistochemical study on hepatic vascular forming factors in liver fibrosis incuced by CCl4 in rats
Jia-Chun Yan, Wen-Bi Chen, Yong Ma and Chang-Jiang Xu
Abstract
AIM To study the relationship between the expressions of hepatic vascular forming factors and liver fibrosis (LF) and liver cirrhosis (LC) induced by CCl4 in rats.
METHODS Fifty 6 month old male SD rats were randomly divided into 2 groups: 40 were used to make model (experimental group) and 10 served as control. The experimental rats were injected with 3mL/kg of 500mL/L CCl4 (prepared with liquid paraffin) on several spots, twice a week and the control group was not treated with CCl4. Ten rats of experimental rats were studied separately on week 2, 5, 8 and 12 after experiment and frost and paraffin slices were made for immunohist-ochemical observation of VEGF, α-SMA and ⅧR Ag. ......
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