大鼠肝纤维化模型中肝细胞凋亡及其调控基因的表达
肝硬化，实验性,病理学;肝,病理学;脱噬作用;基因表达调控,项目负责人,Correspondenceto,Hepatocellularapoptosisanditsapoptosis-regulatinggeneinratliverfibrosismodel,Abstract,AIM,METHODS,RESULTS,CONCLUSION,Sub
湖北医科大学附属第一医院消化内科 湖北省武汉市 430060吕鹏，男,1973-09-03生，山东省济宁市人,汉族. 1996年滨州医学院临床医学系毕业，山东省济宁市第四人民医院住院医师，现为湖北医科大学附属第一医院消化内科硕士研究生，研究方向为消化系疾病的诊治.
项目负责人 罗和生，430060, 湖北省武汉市解放路238号, 湖北医科大学附属第一医院消化内科.
Gastroenterology Division, the First Affiliated Hospital of Hubei Medical University, Wuhan 430060, Hubei Province, China
Correspondence to He-Sheng Luo, Gastroenterology Division, the First Affiliated Hospital of Hubei Medical University, 238 Jiefang Road, Wuhan 430060, Hubei Province, China
Tel. 0086-27-88041911 Ext. 2243
Email. luotang@public.wh.hb.cn
Received 2000-08-08 Accepted 2000-09-18
Hepatocellular apoptosis and its apoptosis-regulating gene in rat liver fibrosis model
Peng Lu, He-Sheng Luo and Bao-Ping Yu
Abstract
AIM To study the effect of hepatocellular apoptosis and apoptosis-regulating gene on the pathogenesis of liver fibrosis.
METHODS Twenty-eight male Wistar rats were randomly divided into 4 groups. A, B, C were experimental groups, while D was normal control group. The rats of experimental groups were intraperitoneally injected with CCl4, and the normal control with normal saline. The rats of group A, B, C were killed after 2, 4, 6 weeks respectively, and those of the normal control were killed at the same time. The livers were taken for pathologic examination, in situ TUNEL and immunohistochemical stain of BAX and BCL-XL by streptavidin peroxidase method. ......
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