人胃腺癌长春新碱耐药细胞MKN28/VCR和MKN45/VCR的建立
胃肿瘤;长春新碱;丁基硫堇亚胺;维拉帕米;药物耐受性;细胞系,本课题为上海市教育委员会基金资助项目,No.96B11,项目负责人,SupportedbytheShanghaiEducationalCommitteeFund,No.96B11,Correspondenceto,Establishment
上海第二医科大学瑞金医院消化科 上海市 200025俞丽芬，女，1970-10-28生，浙江省萧山县人，汉族. 1999年上海第二医科大学硕士毕业.
本课题为上海市教育委员会基金资助项目, No. 96B11
项目负责人 俞丽芬, 200025, 上海市瑞金二路197号,上海第二医科大学瑞金医院消化科.
Department of Gastroenterology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
Supported by the Shanghai Educational Committee Fund, No. 96B11
Correspondence to Li-Fen Yu, Department of Gastroenterology, Ruijin Hospital, Shanghai Second Medical University,Shanghai 200025, China
Tel. 0086-21-64370045
Email. rjnjs @ online. sh. cn.
Received 2000-09-18 Accepted 2000-09-25
Establishment and characterization of vincristine-resistant MKN28/VCR, MKN45/VCR of human gastric cancer cell lines
Li-Fen Yu, Yong-Ping Zhang, Min-Min Qiao and Yun-Lin Wu
Abstract
AIM To study drug resistance mechanism of gastrointestinal tumor, we developed MKN28/VCR, MKN45/VCR which were vincristine-resistant cell lines of human gastric cancer.
METHODS The transmission and scanning electron microscopy and flow cytometry were used to observe the changes of cells＇ ultra-structure and cell cycle distributions. The drug resistance, cross-resistance and reversing drug resistance were studied by MTT. ......
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