大剂量维生素C对肝硬变患者肝功能及细胞免疫功能的影响
抗坏血酸,药理学;抗坏血酸,投药和剂量;肝硬化,药物疗法;肝硬化,病理生理学;肝硬化,免疫学;免疫;细胞;随机对照试验,项目负责人,Correspondenceto:,Effectofhigh-dosevitaminConhepaticfunctionandcellimmunityinpatient
河北医科大学第二医院消化内科 河北省石家庄市 050000张晓岚, 女, 1963-11-21生, 河北省涞源县人, 汉族. 1997年河北医科大学硕士，1999年河北医科大学博士生, 副主任医师, 副教授, 主要从事慢性肝病方面的研究, 发表论文13篇.
项目负责人 姚希贤，050000，河北省石家庄市，河北医科大学第二医院消化内科.
Department of Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
Correspondence to:Xiao Lan Zhang, Department of Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
Tel. 0086-311-7046901 Ext.8632
Email. zxl63@263.net
Received 2001-01-08 Accepted 2001-01-11
Effect of high-dose vitamin C on hepatic function and cell immunity in patients with liver cirrhosis
Zhang-Xiao Lan, Yao-Xi Xian, Li-Yong Jun and Wang-Li Fang
Abstract
AIM To observe the effects of high-dose vitamin C (Vit. C) on hepatic function and cell immunity in cirrhotic patients.
METHODS In the Vit. C-treated group, Vit. C (10g/day) was given intravenously. The plasma Vit. C levels were measured in 58 patients with cirrhosis by high performance liquid chromatography (HPLC). The levels of lymphocyte transformation test (LTT), T lymphocyte phenotype, and red blood cell C3b receptor rosette (RBC-C3bRR) as well as red blood cell immune complex rosette (RBC-ICR) were measured before and after vitamin C therapy. ......
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