恶性阻塞性黄疸患者围手术期外周血淋巴细胞蛋白激酶C活性
胆汁淤积,外科学;淋巴细胞,酶学;蛋白激酶C,代谢;肿瘤坏死因子,代谢,项目负责人,ProteinkinaseCsignalpathwayduringoperationinpatientswithmalignantbileductobstruction,Correspondenceto:,Abstract,AIM,METHODS,RESUL
华中科技大学同济医学院附属同济医院普外科 湖北省武汉市 430030王剑明，男，1968-11-11生，湖北黄石市人，汉族,肝胆外科博士，主治医师 .
项目负责人 王剑明，430030，武汉汉口解放大道1095号.华中科技 大学同济医学院附属同济医院普外科. wjm18jgm@public.wh.hb.cn
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收稿日期 2001-08-24 接受日期 2001-11-21
Protein kinase C signal pathway during operation in patients with malig nant bile duct obstructionJian-Ming Wang and Sheng-Quan Zou
Department of Surgery, Tongji Hospital, Tongji Medical College,Huazh ong Science and Technology, Wuhan,430030,Hubei Province,China
Correspondence to: Jian-Ming Wang, Departmentof Surgery ,Tongji Hospital, Tongji Medical College,Huazhong Science and Technology, Wuhan 430030, Hubei Province,China
Received 2001-08-24 Accepted 2001-11-21
Abstract
AIM To study the roles of protein Kinase C signal pathway du ring the operation and find a new way for treating patients with malignant bile duct obstruction.
METHODS Peripheral blood of normal subjects, and patients with malignant bile duct obstruction before and 1 and 2 weeks after operation was t aken by venipuncture using heparin (25u/ml) as anticoagulant. PKC activities o f peripheral blood lymphocytes were determined by radioactive isotope γ-32P-ATP-catalyzing assay and plasma concentrations of TNFa by ELISA from 31 patients, and was compared with those in normal subjects. ......
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