田耕，于皆平，罗和生，余保平，李建英，武汉大学人民医院消化内科 湖北省武汉市 430060

    田耕，男，1970-09-09生，山西人，汉族，1992年山西医科大学毕业，1996年山西医科大学肝病研究所硕士，现为武汉大学人民医院消化内科博士研究生.发表论文及综述10篇.

    项目负责人 于皆平，430060,武汉大学人民医院消化内科,湖北省武汉市解放路238号.tg3030330@sina.com

    电话: 027-88077184

    收稿日期 2001-09-25 接受日期 2001-10-20

    The expression and effect of cycloox ygenases-2 in acute hepatic injury

    Geng Tian, Jie-Ping Yu, He-Sheng Luo, Bao-Ping Yu, Jian-Ying Li

    Geng Tian, Jie-Ping Yu, He-Sheng Luo, Bao-Ping Yu, Jian-Ying Li. Digestive department. Renmin hospital of Wuhan university, 238 Jie-fang Road, W uhan 430060,Hubei Province, China

    Correspondence to: Pro Jie-Ping Yu, Digestive department. Renm in hospital of Wuhan university, 238 Jie-fang Road, Wuhan 430060,Hubei Province , China.tg3030330@sina.com

    Received 2001-09-25 Accepted 2001-10-20

    

    AbstractAIM:To study the expression of cyclooxygenases-2 and its re lationship with acute hepatic injury.

    METHODS:Fifty Wistar rats were divided into five groups: normal group 10 rats, control group 10 rats receiving ip CCL₄ 1mL·kg^-1, and t hree model groups (10 rats in each group)ip CCL₄ 1mL·kg^-1,and after tw o hours ig Celecoxib 20mg·kg^-1,40mg·kg^-1,80mg·kg^-1 were administered,respectively. ......