慢性丙型肝炎患者干扰素治疗前后HCV HVR1准种的动态变化
慢性丙型肝炎患者干扰素治疗前后HCVHVR1准种的动态变化,张琳,赵桂珍,李颖,石理兰,张琳,项目负责人:,DynamicchangesofHVR1quasispeciesinchronichepatitisCafterIFNtherapy,Correspondenceto:,Received:,Accepted:,Abstract,摘要,目的,:,方法:,结果,结论,0,引言,1材料和方法,1
张琳,赵桂珍,李颖,石理兰,中国医科大学第二临床学院传染科 辽宁省沈阳市 110003张琳,女,1967-06-12生,辽宁省沈阳市人,汉族.1990年大连医学院本科毕业,1997年中国医科大学硕士研究生毕业,讲师.主要从事病毒性肝炎治疗方面的研究.
项目负责人:张琳,110003,辽宁省沈阳市,中国医科大学第二临床学院传染科.
收稿日期:2002-06-08 接受日期:2002-07-05
Dynamic changes of HVR1 quasispecies in chronic hepatitis C after IFN therapy
Lin Zhang,Gui-Zhen Zhao,Ying Li,Li-Lan Shi
Lin Zhang,Gui-Zhen Zhao,Ying Li, Li-Lan Shi,Department of Infectious Disease,The Second Clinical College,China MedicalUniversity,Shenyang110003,Liao Province,China
Correspondence to: Dr.Lin Zhang,Department of Infectious Disease,The Second Clinical College,China Medical University,36 Sanhao Street,Shenyang 110003,LiaoningProvince,China.
Received:2002-06-08 Accepted:2002-07-05
AbstractAIM:To evaluate the correlation between the complexity of HCV HVR1 quasi-species and their response to IFN therapy in patients with chronic hepatitis C.
METHODS:Twenty patients with chronic hepatitis C received IFN therapy (3mu/day, three times/week for 24 weeks). Serum quasispecies complexity of HVR1 was analyzed by polymerase chain reaction mediated singl-strand conformation polymorphism (SSCP) before and 3 months,6 months post-therapy, respectively. ......
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