王如涛, 陈颖伟, 卫新革, 徐芹芳, 李定国, 上海第二医科大学附属新华医院消化内科 上海市 200092

    王如涛, 男, 1949-11-07生, 上海市人, 汉族, 1982年毕业于上海第二医科大学, 1982年至今在上海第二医科大学附属新华医院消化内科工作, 副主任医师, 长期从事肝纤维化的临床和基础研究.

    项目负责人: 李定国, 200092, 上海市控江路1665号, 上海第二医科大学附属新华医院消化内科. dingguo_li@hotmail.com

    电话: 021-65790000-4036 传真: 021-55571294

    收稿日期: 2002-08-17 接受日期: 2002-09-05

    Comparative study of anti-hepatofibr-otic effect of tetrandrine, rhubarb and dipyridamole

    Ru-Tao Wang, Ying-Wei Chen, Xin-Ge Wei, Qin-Fang Xu, Ding-Guo Li

    Ru-Tao Wang, Ying-Wei Chen, Xin-Ge Wei, Qin-Fang Xu, Ding-Guo Li, Department of Gastroenterology, Xinhua Hospital, Shanghai Second Medical University, Shanghai, 200092, China

    Correspondence to: Dr. Ding-Guo Li, Department of Gastroenterology, Xinhua Hospital, Shanghai Second Medical University, Shanghai, 200092, China. dingguo_li@hotmail.com

    Received: 2002-08-17 Accepted: 2002-09-05

    AbstractAIM: To study the antihepatofibrotic mechanism of tetrandrine, rhubarb and dipyridamole.

    METHODS: The experimental hepatic fibrosis was induced by subcutaneous injection of CCl4. The three drugs were administered to male Sprague-Dawley rats by intragastric infusion respectively. Liver function test was performed by enzyme kinetics and the extracellular matrix (ECM) contents were determined by radioimmunoassay. Pathological changes of liver tissues were detected by HE and VG staining, meanwhile, ultra micro-structure changes were observed by electron microscope in randomly selected samples. ......