白介素13在溃疡性结肠炎中的作用
李国栋, 欧阳钦, 四川大学华西医院消化内科 四川省成都市 610041
通讯作者: 欧阳钦,610041, 四川省成都市外南国学巷37号, 四川大学华西医院消化内科. qin_ouyang@tom.com
电话: 028-85442385
收稿日期: 2005-01-11 接受日期: 2005-03-16
摘要IL-13是一种重要的抗炎性细胞因子，与IL-4和IL-10具有类似的特征.在溃疡性结肠炎(UC)中通过多种途径产生抗炎作用，限制炎症的发生和发展.但IL-13在UC中还有另外的作用，这种作用与NK T细胞有关，引起与UC类似的结肠炎症.
, http://www.100md.com
李国栋, 欧阳钦. 白介素13在溃疡性结肠炎中的作用. 世界华人消化杂志 2005;13(8):1017-10201 Farrell RJ, LaMont JT. Microbial factors in inflammatory bowel disease. Gastroenterol Clin North Am 2002;31:41-62
2 Podolsky DK. Inflammation bowel disease. N Engl Med 2002;347:417-429
3 Neurath MF, Finotto S, Glimcher LH. The role of Th1/Th2 polarization in mucosal immunity. Nat Med 2002;8:567-573
4 Van Damme N, De Keyser F, Demetter P, Baeten D, Mielants H, Verbruggen G, Cuvelier C, Veys EM, De Vos M. The
, 百拇医药
proportion of Th1 cells, which prevail in gut mucosa, is decreased in inflammatory bowel syndrome.
Clin Exp Immunol 2001;125:383-390
5 MacDonald TT, Monteleone G, Pender SL. Recent developments in the immunology of inflammatory bowel disease.
Scand J Immunol 2000;51:2-9
6 Wynn TA. IL-13 effectorfunctions. Annu Rev Immunol 2003;21:421-456
, http://www.100md.com
7 Heller F, Fuss IJ, Nieuwenhuis EE, Blumberg RS, Strober W. Oxazolone colitis, a Th2 colitis model resembling ulcerative
colitis, is medicated by IL-13-producing NK-T cells. Immunity 2002;17:629-638
8 Fuss IJ, Heller F, Boirivant M, Leon F, Yoshida M, Fichtner-Feigl S, Yang Z, Exley M, Kitani A, Blumberg RS, Mannon P,Strober W. Nonclassical CD1d-restricted NK-T cells that produce IL-13 characterize an atypical Th2 response in
, 百拇医药
ulcerative colitis. J Clin Invest 2004;113:1490-1497
9 戴胜兰, 白文元. 白介素13的生物学特性与肝纤维化. 国外医学内科学分册 2003;30:427-430
10 Boulay JL, Paul WE. The interleukin-4-related lymphokines and their binding to hematopoietin receptors.
J Biol Chem 1992;267:20525-20528
11 McKenzie AN, Li X, Largaespada DA, Sato A, Kaneda A, Zurawski SM, Doyle EL, Milatovich A, Francke U, Copeland NG.
, 百拇医药
Structure comparison and chromosomal localization of the human and mouse IL-13 genes.
J Immunol 1993;150:5436-5444
12 Hershey GK. IL-13 receptors and singaling pathways: An evolving web. J Allergy Clin Immunol 2003;111:677-690
13 Kawakami K, Taguchi J, Murata T, Puri RK. The interleukin-13 receptor alpha2 chain:an essential component for
binding and internalization but not for interleukin-13-induced signal transduction through the STAT6 pathway.
, http://www.100md.com
Blood 2001;97:2673-2679
14 Gauchat JF, Schlagenhauf E, Feng NP, Moser R, Yamage M, Jeannin P, Alouani S, Elson G, Notarangelo LD, Wells T,Eugster HP, Bonnefoy JY. A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human B, T and endothelial
cells encoding an alternate type-II interleukin-4/interleukin-13 receptor. Eur J Immune 1997;27:971-980
15 Punnonen J, Aversa G, Cocks BG, McKenzie AN, Menon S, Zurawski G, de Waal Malefyt R, de Vries JE. Interleukin-13
, http://www.100md.com
induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cell. Proc Natl Acad Sci USA
1993;90:3730-3736
16 Coste A, Dubourdeau M, Linas MD, Cassaing S, Lepert JC, Balard P, Chalmeton S, Bernad J, Orfila C, Seguela JP,Pipy B. PPARg promotes mannose receptor gene expression in murine macrophages and contributes to the induction
of this receptor by IL-13. Immunity 2003;19:329-339
, http://www.100md.com
17 Ashwood P, Harvey R, Verjee T, Wolstencroft R, Thompson RP, Powell JJ. Functional interactions between mucosal
IL-1, IL-ra and TGF-beta in ulcerative colitis. Inflamm Res 2004;53:53-59
18 Kurtovic J, Segal I. Recent advances in biological therapy for inflammation bowel disease. Trop Gastroenterol
2004;25:9-14
19 Linehan JD, Kolios G, Valatas V, Robertson DA, Westwick J. Effect of corticosteroids on nitric oxide production in
, http://www.100md.com
inflammatory bowel disease: are leukocytes the site of action? Am J Physiol Gastrointest Liver Physiol
2005;288:G261-267
20 Menchen L, Colon AL, Madrigal JL, Beltran L, Botella S, Lizasoain I, Leza JC, Moro MA, Menchen P, Cos E, Lorenzo P.
Activity of inducible and neuronal nitric oxide synthases in colonic mucosa predicts progression of ulcerative colitis.
, http://www.100md.com Am J Gastroenterol 2004;99:1756-1764
21 Kolios G, Rooney N, Murphy CT, Robertson DA, Westwick J. Expression of inducible nitric oxide synthase activity in
human colon epithelial cells:modulation by T lymphocyte derived cytokines. Gut 1998;43:56-63
22 周宇, 叶文桃, 麦海妍, 郭汉城, 王翠霞. 白介素13和一氧化氮在溃疡性结肠炎的作用及意义.
胃肠病学和肝病学杂志 2004;13:319-321
, 百拇医药 23 Kelly D, Campbell JI, King TP, Grant G, Jansson EA, Coutts AG,Pettersson S, Conway S. Commensal anaerobic
gut bacteria attenuate inflammationby regulating nuclear-cytoplasmic shutting of PPAR-gamma and RelA.
Nat Immunol 2004;5:104-112
24 Bassaganya-Riera J, Reynolds K, Martino-Catt S, Cui Y, HennighausenL, Gonzalez F, Rohrer J, Benninghoff AU,Hontecillas R. Activation of PPAR-gammaand delta by conjugated linoleic acid mediates protection fromexperimental
, 百拇医药
inflammation bowel disease. Gastroenterology 2004;127:777-791
25 张燕, 欧阳钦, 陈岱云. PPAR-g在溃疡性结肠炎黏膜中的表达. 中华消化内镜杂志 2002;19:81-83
26 Manna SK, Aggarwal BB. IL-13 suppresses TNF-induced activation of nuclear factor-kappa B, activation protein-1,and apoptosis. J Immunol 1998;161:2863-2872
27 Bonen DK, Cho JH. The genetics of inflammatory bowel disease. Gastroenterology 2003;124:521-536
, http://www.100md.com
28 Karban AS, Okazaki T, Panhuysen CI, Gallegos T, Potter JJ, Bailey-Wilson JE, Silverberg MS, Duerr RH, Cho JH,Gregersen PK, Wu Y, Achkar JP, Dassopoulos T, Mezey E, Bayless TM, Nouvet FJ, Brant SR. Functional annotation
of a novel NF-kB1 promoter polymorphism that increases risk for ulcerative colitis. Hum Mol Genet 2004;13:35-45
29 Hollenbach E, Neumann M, Vieth M, Roessner A, Malfertheiner P, Naumann M. Inhibition of p38 MAP kinase- and
, 百拇医药
RICK/NF-kappaB-signaling suppresses inflammatory bowel disease. FASEB J 2004;18:1550-1552
30 Tang HF, Chen XX, Ye HY, Ou BY. Expression of tumor necrosis factor-alpha and nuclear factor-kappa B in
childhood ulcerative colitis. Zhonghua Erke Zazhi 2003;41:743-746
31 Wang QY, Chen CL, Wang JD, Lai ZS, Ma Q, Zhang YL. Expression of pro-inflammation cytokines and activation of
, 百拇医药
nuclear factor kappab in the intestinal mucosa of mice with ulcerative colitis. Diyi Junyi Daxue Xuebao
2003;23:1202-1205
32 Gan H, Ouyang Q, Jia D, Xia Q. Activation of nuclear factor-kappaB and its relationship with cytokine gene expression
in colonic mucosa of ulcerative colitis patients. Chung-Hua Nei Ko Tsa Chih Chine J Internal Med 2002;41:252-255
33 Tak PP, Firestein GS. NF-kappaB: a key role in inflammatory diseases. J Clin Invest 2001;107:7-11
, http://www.100md.com
34 Mikami T, Yoshida T, Akino F, Motoori T, Yajima M, Okayasu I. Apoptosis regulation differs between ulcerative
colitis-associated and sporadic colonic tumors. Association with survivin and bcl-2. Am J Clin Pathol 2003;119:723-730
35 Peppelenbosch MP, van Deventer SJ. T cell apoptosis and inflammatory bowel disease. Gut 2004;53:1556-1558
36 Bouma G, Strober W. The immunological and genetic basis of inflammation bowel disease.
, 百拇医药
Nature Reviews 2003;3:521-533
37 Aldebert D, Notteghem B, Reumaux D, Lassalle P, Lion G, Desreumaux P, Duthilleul P, Colombel JF. Anti-endothelial
cell antibodies in sera from patients with inflammatory bowel disease. Gastroenterol Clin Biol 1995;19:867-870
编辑 张海宁, 百拇医药( 李国栋,欧阳钦)
通讯作者: 欧阳钦,610041, 四川省成都市外南国学巷37号, 四川大学华西医院消化内科. qin_ouyang@tom.com
电话: 028-85442385
收稿日期: 2005-01-11 接受日期: 2005-03-16
摘要IL-13是一种重要的抗炎性细胞因子，与IL-4和IL-10具有类似的特征.在溃疡性结肠炎(UC)中通过多种途径产生抗炎作用，限制炎症的发生和发展.但IL-13在UC中还有另外的作用，这种作用与NK T细胞有关，引起与UC类似的结肠炎症.
, http://www.100md.com
李国栋, 欧阳钦. 白介素13在溃疡性结肠炎中的作用. 世界华人消化杂志 2005;13(8):1017-10201 Farrell RJ, LaMont JT. Microbial factors in inflammatory bowel disease. Gastroenterol Clin North Am 2002;31:41-62
2 Podolsky DK. Inflammation bowel disease. N Engl Med 2002;347:417-429
3 Neurath MF, Finotto S, Glimcher LH. The role of Th1/Th2 polarization in mucosal immunity. Nat Med 2002;8:567-573
4 Van Damme N, De Keyser F, Demetter P, Baeten D, Mielants H, Verbruggen G, Cuvelier C, Veys EM, De Vos M. The
, 百拇医药
proportion of Th1 cells, which prevail in gut mucosa, is decreased in inflammatory bowel syndrome.
Clin Exp Immunol 2001;125:383-390
5 MacDonald TT, Monteleone G, Pender SL. Recent developments in the immunology of inflammatory bowel disease.
Scand J Immunol 2000;51:2-9
6 Wynn TA. IL-13 effectorfunctions. Annu Rev Immunol 2003;21:421-456
, http://www.100md.com
7 Heller F, Fuss IJ, Nieuwenhuis EE, Blumberg RS, Strober W. Oxazolone colitis, a Th2 colitis model resembling ulcerative
colitis, is medicated by IL-13-producing NK-T cells. Immunity 2002;17:629-638
8 Fuss IJ, Heller F, Boirivant M, Leon F, Yoshida M, Fichtner-Feigl S, Yang Z, Exley M, Kitani A, Blumberg RS, Mannon P,Strober W. Nonclassical CD1d-restricted NK-T cells that produce IL-13 characterize an atypical Th2 response in
, 百拇医药
ulcerative colitis. J Clin Invest 2004;113:1490-1497
9 戴胜兰, 白文元. 白介素13的生物学特性与肝纤维化. 国外医学内科学分册 2003;30:427-430
10 Boulay JL, Paul WE. The interleukin-4-related lymphokines and their binding to hematopoietin receptors.
J Biol Chem 1992;267:20525-20528
11 McKenzie AN, Li X, Largaespada DA, Sato A, Kaneda A, Zurawski SM, Doyle EL, Milatovich A, Francke U, Copeland NG.
, 百拇医药
Structure comparison and chromosomal localization of the human and mouse IL-13 genes.
J Immunol 1993;150:5436-5444
12 Hershey GK. IL-13 receptors and singaling pathways: An evolving web. J Allergy Clin Immunol 2003;111:677-690
13 Kawakami K, Taguchi J, Murata T, Puri RK. The interleukin-13 receptor alpha2 chain:an essential component for
binding and internalization but not for interleukin-13-induced signal transduction through the STAT6 pathway.
, http://www.100md.com
Blood 2001;97:2673-2679
14 Gauchat JF, Schlagenhauf E, Feng NP, Moser R, Yamage M, Jeannin P, Alouani S, Elson G, Notarangelo LD, Wells T,Eugster HP, Bonnefoy JY. A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human B, T and endothelial
cells encoding an alternate type-II interleukin-4/interleukin-13 receptor. Eur J Immune 1997;27:971-980
15 Punnonen J, Aversa G, Cocks BG, McKenzie AN, Menon S, Zurawski G, de Waal Malefyt R, de Vries JE. Interleukin-13
, http://www.100md.com
induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cell. Proc Natl Acad Sci USA
1993;90:3730-3736
16 Coste A, Dubourdeau M, Linas MD, Cassaing S, Lepert JC, Balard P, Chalmeton S, Bernad J, Orfila C, Seguela JP,Pipy B. PPARg promotes mannose receptor gene expression in murine macrophages and contributes to the induction
of this receptor by IL-13. Immunity 2003;19:329-339
, http://www.100md.com
17 Ashwood P, Harvey R, Verjee T, Wolstencroft R, Thompson RP, Powell JJ. Functional interactions between mucosal
IL-1, IL-ra and TGF-beta in ulcerative colitis. Inflamm Res 2004;53:53-59
18 Kurtovic J, Segal I. Recent advances in biological therapy for inflammation bowel disease. Trop Gastroenterol
2004;25:9-14
19 Linehan JD, Kolios G, Valatas V, Robertson DA, Westwick J. Effect of corticosteroids on nitric oxide production in
, http://www.100md.com
inflammatory bowel disease: are leukocytes the site of action? Am J Physiol Gastrointest Liver Physiol
2005;288:G261-267
20 Menchen L, Colon AL, Madrigal JL, Beltran L, Botella S, Lizasoain I, Leza JC, Moro MA, Menchen P, Cos E, Lorenzo P.
Activity of inducible and neuronal nitric oxide synthases in colonic mucosa predicts progression of ulcerative colitis.
, http://www.100md.com Am J Gastroenterol 2004;99:1756-1764
21 Kolios G, Rooney N, Murphy CT, Robertson DA, Westwick J. Expression of inducible nitric oxide synthase activity in
human colon epithelial cells:modulation by T lymphocyte derived cytokines. Gut 1998;43:56-63
22 周宇, 叶文桃, 麦海妍, 郭汉城, 王翠霞. 白介素13和一氧化氮在溃疡性结肠炎的作用及意义.
胃肠病学和肝病学杂志 2004;13:319-321
, 百拇医药 23 Kelly D, Campbell JI, King TP, Grant G, Jansson EA, Coutts AG,Pettersson S, Conway S. Commensal anaerobic
gut bacteria attenuate inflammationby regulating nuclear-cytoplasmic shutting of PPAR-gamma and RelA.
Nat Immunol 2004;5:104-112
24 Bassaganya-Riera J, Reynolds K, Martino-Catt S, Cui Y, HennighausenL, Gonzalez F, Rohrer J, Benninghoff AU,Hontecillas R. Activation of PPAR-gammaand delta by conjugated linoleic acid mediates protection fromexperimental
, 百拇医药
inflammation bowel disease. Gastroenterology 2004;127:777-791
25 张燕, 欧阳钦, 陈岱云. PPAR-g在溃疡性结肠炎黏膜中的表达. 中华消化内镜杂志 2002;19:81-83
26 Manna SK, Aggarwal BB. IL-13 suppresses TNF-induced activation of nuclear factor-kappa B, activation protein-1,and apoptosis. J Immunol 1998;161:2863-2872
27 Bonen DK, Cho JH. The genetics of inflammatory bowel disease. Gastroenterology 2003;124:521-536
, http://www.100md.com
28 Karban AS, Okazaki T, Panhuysen CI, Gallegos T, Potter JJ, Bailey-Wilson JE, Silverberg MS, Duerr RH, Cho JH,Gregersen PK, Wu Y, Achkar JP, Dassopoulos T, Mezey E, Bayless TM, Nouvet FJ, Brant SR. Functional annotation
of a novel NF-kB1 promoter polymorphism that increases risk for ulcerative colitis. Hum Mol Genet 2004;13:35-45
29 Hollenbach E, Neumann M, Vieth M, Roessner A, Malfertheiner P, Naumann M. Inhibition of p38 MAP kinase- and
, 百拇医药
RICK/NF-kappaB-signaling suppresses inflammatory bowel disease. FASEB J 2004;18:1550-1552
30 Tang HF, Chen XX, Ye HY, Ou BY. Expression of tumor necrosis factor-alpha and nuclear factor-kappa B in
childhood ulcerative colitis. Zhonghua Erke Zazhi 2003;41:743-746
31 Wang QY, Chen CL, Wang JD, Lai ZS, Ma Q, Zhang YL. Expression of pro-inflammation cytokines and activation of
, 百拇医药
nuclear factor kappab in the intestinal mucosa of mice with ulcerative colitis. Diyi Junyi Daxue Xuebao
2003;23:1202-1205
32 Gan H, Ouyang Q, Jia D, Xia Q. Activation of nuclear factor-kappaB and its relationship with cytokine gene expression
in colonic mucosa of ulcerative colitis patients. Chung-Hua Nei Ko Tsa Chih Chine J Internal Med 2002;41:252-255
33 Tak PP, Firestein GS. NF-kappaB: a key role in inflammatory diseases. J Clin Invest 2001;107:7-11
, http://www.100md.com
34 Mikami T, Yoshida T, Akino F, Motoori T, Yajima M, Okayasu I. Apoptosis regulation differs between ulcerative
colitis-associated and sporadic colonic tumors. Association with survivin and bcl-2. Am J Clin Pathol 2003;119:723-730
35 Peppelenbosch MP, van Deventer SJ. T cell apoptosis and inflammatory bowel disease. Gut 2004;53:1556-1558
36 Bouma G, Strober W. The immunological and genetic basis of inflammation bowel disease.
, 百拇医药
Nature Reviews 2003;3:521-533
37 Aldebert D, Notteghem B, Reumaux D, Lassalle P, Lion G, Desreumaux P, Duthilleul P, Colombel JF. Anti-endothelial
cell antibodies in sera from patients with inflammatory bowel disease. Gastroenterol Clin Biol 1995;19:867-870
编辑 张海宁, 百拇医药( 李国栋,欧阳钦)
