【摘要】 目的 寻找不同发育阶段人毛囊-皮脂腺单位中C/EBPα和C/EBPβ的表达变化规律及与毛囊皮脂腺分化的关系。方法 应用免疫组化方法检测胚胎及新生儿和成人毛囊皮脂腺组织中C/EBPα和C/EBPβ的定位及表达。结果 C/EBPα和C/EBPβ分别在胚胎期毛囊外根鞘，毛乳头，毛母质及皮脂腺细胞的胞核内强表达;新生儿毛囊峡部下端外根鞘基底层细胞的胞核内也存在强表达，基底内层胞核阳性信号逐渐减弱;而成体毛囊核内阳性信号仅定位于峡部下端外根鞘基底层及皮脂腺基底层。毛囊外根鞘内层细胞随分化程度升高，胞浆内C/EBPα和C/EBPβ的表达逐渐升高，毛乳头细胞则未见阳性颗粒。在整个毛囊皮脂腺发育过程中C/EBPα的表达都略强于C/EBPβ。结论 C/EBPα和C/EBPβ在不同发育阶段的毛囊皮脂腺单位中均有表达，定位及表达水平与分化程度密切相关。

    关键词 毛囊-皮脂腺单位 C/EBPs 分化

    Characteristics of C/EBPs protein expressions in the pilo-sebaceous unit of human at different developmental stage and their biological significance

    Zheng Yehua，Yang Tian，Gao Qiangguo

    Department of Cell Biology，Third Military Medical University，Chongqing400038.

    【Abstract】 Objective To study the expression of C/EBPαand C/EBPβprotein in human piol-sebaceous uˉnit during different developmental stage.Methods C/EBPαand C/EBPβprotein expressions were studied by using immunohistochemical method.Results C/EBPαand C/EBPβexpressed differently in the outer root sheath ......