【摘要】 目的 探讨硒对新生儿神经行为发育和甲状腺功能调节的作用。方法 采用Ebselen对围产期铅暴露进行干预流调，测定脐血铅、血硒及促甲状腺素、活性甲状腺素，在新生儿出生后第26～28天采用双盲法进行神经行为发育(NBNA)评价。结果 干预组脐血铅均值为0.34μmol/L，显著低于对照组的0.5μmol/L，血硒、血锌、GSH-P X 均高于对照组(P<0.01)，TT 3 、TT 3 /TT 4 比值、FT 3 /FT 4 比值均高于对照组。结论 采用硒干预对降低新生儿铅中毒，改善微量营养素，提升抗氧化功能，改善甲状腺功能代谢，保护新生儿智力正常发育有明显促进作用。

    Cai Wende，Zhang Jing，Duan Lihua，et al.

    Shenzhen Center for Control and Prevention of Diseases，Guangdong518020.

    【Abstract】 Objective To explore the effect of perinatal lead intervention on the development of newborn’s nervous behavior and throxine.Methods The intervention epide miological investigation was proceeded with the perinatal lead exposure by using Ebselen，and the umbilical blood lead was detected by atomic absorption method and the umbilical blood selenium was detected by double ways fluoreson day26～28of newborn was evaluated by using double blind method.Results The navel blood lead of intervention group was0.34μmol/L ......