【摘要】 目的 探讨儿童糖尿病病人血、尿一氧化氮水平及意义。方法 采用镉柱层析还原法，测定125例T1DM患儿尿硝酸盐(NO -3 )含量，同时测定55例患儿血NO -3 及正常健康儿童30例血、尿NO -3 的测定。结果 儿童1型糖尿病(T1DM)患儿尿NO -3 尿排泄量显著增加，并随着尿糖的转阴而减低，同时随着病程延长血糖的控制不满意而减低，尿NO -3 水平有逐渐下降趋势。结论 NO -3 水平降低提示肾脏内皮细胞功能的损害，糖尿病肾病的进行性加重。

    关键词 1型糖尿病(T1DM) 一氧化氮 糖尿病肾病

    Relationship between change to serum and urine nitric oxide level and occurrence&development of nephropathy in the children with type1diabetes mellitus

    Chen Zhaowen，Chen Ye，Zhou Haiyan，et al.

    Department of Paediatric，Jinshan Hospital Affiliated to Fudan University，Shanghai200540.

    【Abstract】 Objective To investigate the serum and urine nitric oxide level in diabetic children.Methods Urine nitrate(NO -3 )level measured in125children with T1DM and serum NO -3 level also measured;in55children of them were compared with both serum and urinary NO -3 level in30healthy children.Results Urinary NO -3 excretion in the children with T1DM remarkably increased ......