【摘要】 目的 探讨急性肾小球肾炎发生及发展与HLA-DRB 1 等位基因的关系，寻找该病的HLA-DRB 1 易感基因。方法 采用序列特异性引物-聚合酶链反应方法对急性肾小球肾炎患儿和正常儿童的HLA-DRB 1 等位基因进行分析，并分析了HLA-DRB 1ˇ 15基因型在急性肾小球肾炎中所起的作用。结果 急性肾小球肾炎患儿HLA-DRB 1ˇ 15基因频率为(16.25%)，与正常对照组比较差异有非常显著性(P<0.01);HLA-DRB 1ˇ 15型急性肾小球肾炎患儿临床症状表现重。结论 HLA-DRB 1 基因型对急性肾小球肾炎的发生、发展有一定的影响;探讨急性肾小球肾炎的HLA-DRB 1 基因型对于病情预测有重要意义。

    关键词 急性肾小球肾炎 HLA-DRB 1 基因 ssp/PCR

    The influence of HLA gene on acute glomerulonephritis

    Jiao Lixin，Sun Liwei，Liu Yuqi

    Children′s Hospital of Changchun130061.

    【Abstract】 Objective To study the relation between acute glomerulonephritis occurence and development and HLA gene，then to find HLA predisposing gene of this disease.Methods Using ssp-PCR method to study acute glomerulonephritis patient’s HLA gene and assay different clinical situations of different HLA gene types.Results The gene frequency of acute glomerulonephritis patients is16.25%.It is significantly higher than normal control group(P<0.01);Acute glomerulonephritis patients who was HLA-DRB 1ˇ 15were more severe.Conclusion The occurˉrenc ......