Li Shaodan，Yuan Benli

    302Hospital of PLA，Beijing100039.

    【Abstract】 Objective To study effects of NO(nitrogen monoxide)and LP(lipid peroxidation)on hepatic inˉjury induced by ConA(Concanavalin A.)Methods 56BALB/c male mice were randomly divided into two groups.NS(normal saline，0.2ml)was injected intraperitoneally to be regarded as the control group.ConA(Concanavalin A，20mg/kg)in NS was injected intraperitoneally to be served as the test group.Plasma samples for ALT，AST，NO 2- measurements were obtained at3，6，9and12h after respective treatments，meanwhile contents of MDA(malondialdeˉhyde)of liver tissue homogenate was detected.Results In the test group，the level of ALT，AST，NO 2- in plasma was ascending sharply(P<0.01，vs the control group at12h).Contents of MDA in liver tissure homogenate of the test group were increasing continuously(P<0.01，vs the test groups at12h).There were little changes of ALT ......