【摘要】 目的 观察胸腺五肽联合乙肝疫苗治疗慢性乙型肝炎的疗效。方法 应用时间分辨免疫荧光分析法检测胸腺五肽联合乙肝疫苗治疗组、单用乙肝疫苗治疗组、单用胸腺五肽组、一般护肝组治疗前后乙肝病毒标志物滴度的变化。结果 胸腺五肽联合乙肝疫苗组HBsAg、HBsAb、HBeAg滴度较其他组差异有显著性(P<0.05)，HBeAb差异无显著性(P>0.05);联合组治疗后HBV-DNA阴转率与单用乙肝疫苗治疗组、单用胸腺五肽组差异无显著性(P>0.05)，与一般治疗组的差异有显著性(P<0.05)。结论 胸腺五肽联合乙肝疫苗有明显降低HBsAg、HBeAg和升高HBsAb的作用，是治疗慢性乙型肝炎有效的治疗方法。

    关键词 胸腺五肽 乙肝疫苗 慢性乙型肝炎 时间分辨免疫荧光分析

    Analysis on therapeutic effectiveness of thymopentin combination with hepatitis B vaccine on patients suffered from chronic hepatitis

    B He Xing’e，Tang Xianming，Wang Gufeng，et al.

    Liver Disease Research Center，The Second Xiangya Hospital of Central South University，Changsha410011.

    【Abstract】 Objective To observe therapeutic effectiveness of Thymopentin combined with hepatitis B vaccine on patients suffered from chronic hepatitis B(CHB).Methods To detect the alteration of HBV-M tite of Thyˉmopentin combinated with hepatitis B vaccine、single hepatitis B vaccine or Thymopentin and regular treatment group by time-reolved fluoroimmunoassay(TRF).Results HBsAg、HBsAb、HBeAg tite of Combination group had deˉcreased significantly compared with hepatitis B vaccine、Thymopentin and regular treatment group(P<0.05);HBV-DNA negative rate of Combination group had increased significantly compared with regular treatment group(P<0.05).Conclusion Thymopentin sombinated with hepatitis B vaccine which can significantly decrease HBsAg、HBeAg tite and increase HBsAb tite ......