hMSH2、hMLH1的表达与胃癌临床病理及预后的关系
hMSH2,hMLH1,hMSH2,hMLH1,胃癌,临床病理,预后,1材料及方法,2结果,3讨论,参考文献
【摘要】 目的 探讨错配修复基因hMSH2、hMLH1蛋白的表达与胃癌临床病理学特性预后之间的关系。方法 采用免疫组织化学方法检测40例胃癌中hMSH2、hMLH1蛋白的表达情况,并对40例胃癌患者的3年存活情况进行随访。结果 40例胃癌标本中,hMSH2减低表达率为35%,hMLH1蛋白降低表达率为52.5%;淋巴结转移阳性的胃癌中,hMSH2、hMLH1蛋白表达明显减低(P<0.05),并且hMSH2、hMLH1蛋白表达减低的胃癌患者生存率有降低趋势。结论 hMSH2、hMLH1蛋白表达与胃癌的发生和淋巴结转移有关。关键词 hMSH2 hMLH1 胃癌 临床病理 预后
The study on expression of hMSH2and hMLH1in relation to clinicopathology and prognosis of gastric cancer
Guo Cheng,Che Xiangming,Fan Lin,et al.
General Surgery,First Hospital,Xi′an Jiao Tong University,Xi′an710061.
【Abstract】 Objective To investigate the expression of mismatch repair genes hMSH2and hMLH1in gastric cancer and their clinicopathologial significance.Methods Immunohistochemistry staining was used to detect the exˉpression of hMSH2and hMLH1in40cases of gastric cancer.All cases were followed-up for3years.Results In40cases with gastric cancer ......
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