【摘要】 目的 探讨干姜提取物和四逆汤对心衰兔心脏舒缩性能的作用异同。方法 以40只纯种新西兰兔为研究对象，随机分为高、中、低剂量干姜组和四逆汤组共4组，用恒速滴注戊巴比妥钠的方法建立兔急性心力衰竭模型，造模成功后，经口插管入胃灌服受试品，用RM-600四道生理仪测定造模前、造模成功时及用药后5min、10min、15min、20min、30min、45min、60min、90min、120min、150min兔的心肌舒缩性能指标，观察各时段指标的变化情况。结果 (1)干姜提取物和四逆汤均能使心衰兔的LVSP、LV±dp/dtmax、LV+dp/dtmax和LV-dp/dtmax呈逐渐上升趋势，中、高剂量干姜组的作用明显优于四逆汤组，差异有显著或非常显著性，P<0.05或P<0.001;(2)两者均能使t-dp/dtmax和LVET呈逐渐缩短趋势;(3)四逆汤组药后各时点LVEDP与药前值比较均未见差异，而各剂量干姜组药后各时点LVEDP呈下降趋势，尤以高剂量组下降趋势明显，在药后10～150min各时点，与药前值比较差异有非常显著性，P<0.001。结论 干姜提取物和四逆汤均具有增强心肌收缩和舒张性能、降低外周阻力作用，以干姜提取物的作用更强;同时干姜提取物在降低舒张末期压方面具有优势，更有利于减轻心脏前负荷，改善冠脉灌流。

    关键词 心力衰竭 动物模型 干姜提取物 四逆汤 心肌舒缩性能

    Lu Chuanjian，Xu Qingwen，Ou Ming，et al.

    Guangzhou University of Traditional Chinese Medicine，Guangzhou510405.

    【Abstract】 Objective To investigate the difference between the effects of Ginger Extract and4-Retro-deˉcoction(Si-ni Tang)on cardiac systolic/diastolic function of rabbit with heart failure.Methods 40pure-breed New-Zealand rabbits were randomly divided into4groups:low(0.028mL/kg)，middle(0.056mL/kg)，high(0.112mL/kg)dosage ginger group and4-Retro-decoction group.The heart failure model of rabbit was established by intravenous administration of20g/L pentobarbital sodium at a certain rate.Oral tube perfusion of ginger extract and4-Retro-decoction were administrated after the establishment of the model.Their hemodynamic changes were detected before and after the model establishment ......