【摘要】 目的 回顾抗精神病药(APD)临床药理研究发展史，思考并展望未来研究方向，为设计创新更有效的治疗方案和新的APD提供信息。方法 检索相关文献，总结分析该类药作用机制及其临床药理学、药效学、药动学的研究进展历程和应用现状。结果 典型APD主要作用于多巴胺(DA)受体，非典型APD则以五羟色胺(5-HT)及其他受体为主，前者不良反应较大，后者较小。结论 DA与5-HT受体多肽性的研究会启发人们开发出针对特定遗传特征的群体和亚群的药物。多受体及其配比关系，新受体的发现则是APD临床药理研究的另一新方向。

    Xie Shoudun，Xie Xianfei

    Wuhan Mental Health Center，Wuhan430022.

    【Abstract】 Objective To review the develop history of the clinical pharmacological research of antipsychotic drug(APD)，think and look ahead futures study direction and provide information for designing more effective treatment and new APD.Methods To retrieve pertinent literature，analyse and summarize action mechanism research progress in clinical pharmacology and status quo of this kind of drug.Results Typical APD is mainly action on dopamine(DA)receptor，but atypical APD is on serotonin(5-HT)receptor，the formar has more adverse reaction than the latˉter.Conclusion The research of polypeptide character in DA and5-HT receptors can enlighten people to develop drug aiming directly at group and subgroup of definite hereditary feature.Many receptors and their match relation the discovery of new receptor is another direction for clinical pharmacological research of APD. ......