【摘要】 目的 观察雌激素对绝经后妇女血管内皮功能的影响，探讨雌激素对心血管的预防效应。方法 58例绝经后妇女患者随机分为治疗组和安慰剂组，治疗组病人每天服用雌激素(倍美力，苏州立达)0.625mg，安慰剂组每天服用安慰剂1片，观察治疗6个月后，用高分辨力超声检测雌激素替代治疗(ERT)前后动脉血管的血流介导性舒张反应，测定血浆雌二醇、一氧化氮(NO)、内皮素(ET-1)和血脂水平。结果 治疗组治疗后动脉血流介导性舒张反应性(FMD%)显著改善(P<0.001)，对硝酸甘油的反应(NTGD%)差异无显著性(P>0.05)，血清雌二醇和一氧化氮水平显著升高(P<0.001)，ET-1显著降低(P<0.01)，血总胆固醇、低密度脂蛋白显著降低(P<0.05)，安慰剂组则变化不大。结论 ERT能改善绝经后妇女患者血管内皮功能及脂代谢，有助于绝经妇女的冠心病一级预防。

    关键词 雌激素 绝经妇女 血管内皮功能 超声检查

    Evaluation of estrogen on vascular endothelium function in postmenopausal women by the high-resolution ultrasound

    Wu Huimin，Zhang Ruihong，Li Liqiang

    Department of Cardiology，XuZhou First People’s Hospital of Jangsu，Jiangsu221002

    【Abstract】 Objective To study the effect of estrogen on vascular endothelium function in postmeopausal women and its beneficial effects on cardiovascular system.Methods 58postmenopausal women were randomly divided into treatment and placebo groups.Received estrogen0.625mg per day and placebo was observed respectively for6months.Flowmediated vasodilatory response(FMD)of the brachial artery in estrogen replacement therapy(ERT)and placebo group was measured by high resolution ultra sonography menthod.Plasama lipids ......