【摘要】 目的 研究大黄素和黄芪多糖联合给药抑制大鼠肝癌发生、发展的作用。方法 采用二乙基亚硝胺(diethylniˉtrosamine，DEN)诱发的大鼠肝癌模型，SD大鼠60只随机分为5组，诱癌同时给予大黄素和黄芪多糖干预治疗。从实验第8周开始每周处死部分大鼠，化验血清肝功指标ALT、γ-GT和α-岩藻糖苷酶(α-L-fucoxidase，AFU)，并行病理检查，实验第18周处死所有大鼠。结果 大黄素和黄芪多糖联合给药组的体重、各项肝功指标、肝癌发生的时间和病理分级均较模型组有明显改善。结论 联合给予大黄素和黄芪多糖对大鼠肝癌的发生、发展有一定的抑制作用。

    关键词 黄芪多糖 大黄素 肝癌 中药

    Inhibitory effect of emodin and astragalus polysaccharides on hepatocarcinoma in rats

    Yuan Lichao，Cheng Yan’an，Dang Shuangsuo，et al.

    Department of Infectious Diseases，The Second Hospital of Xi’an Jiaotong University，Xi’an710004

    【Abstract】 Objective To study the inhibitory effect of emodin and astragalus polysaccharides on hepatocarcinoˉma in rats.Methods We used rat hepatocarcinogenesis model induced by diethylnitrosamine(DEN).Rats were adminˉistered with emodin and astragalus polysaccharides when they were induced by DEN.To be tested serum indexes ALT ......