【摘要】 目的 观察电针对局脑缺血再灌注大鼠脑组织中C-fos蛋白表达的影响。方法 利用大鼠大脑中动脉阻塞再灌流模型，采用免疫组化染色(SP法)测定C-fos蛋白表达。结果 假手术组C-fos阳性细胞百分率1.12±0.74;缺血组C-fos阳性细胞百分率为17.15±2.76;电针组C-fos阳性细胞百分率为11.32±1.97;缺血组与假手术组比较C-fos明显升高(P<0.01);电针组与缺血组比较C-fos降低(P<0.05)。结论 表明局部脑缺血可诱导脑组织C-fos蛋白的表达，而电针对脑局部缺血后C-fos蛋白表达有明显抑制作用。

    protein in rat brain after MCAO and reperfusion

    Jiao Jianling，Lai Xinsheng，Zhang Jiawei，et al.

    Medical School，Jinan University，Guangzhou510632.

    【Abstract】 Objective To study the influence of electric-acupuncture on expression of C-fos protein in rat brain after MCAO and reperfusion.Methods The middle cerebral artery occlusion(MCAO)model and SPC were used.Results The C-fos expression rate of the sham-operated group:1.12±0.74;The C-fos expression rate of the ischemia group:17.15±2.76;The C-fos expression rate of the electric-acupuncture group:11.32±1.97.The C-fos expression of the ischemia group compared with the sham-operated group increases(P<0.01);The C-fos expression of electric-acupuncture group compared with the ischemia group decreased(P<0.05).Conclusion Loˉcal cerebral ischemia results in increase of C-fos expression ......