奥沙利铂对胃癌OCUM-2MD3细胞体内外杀瘤活性的实验研究
抗肿瘤,胃癌,奥沙利铂,OCUM-2MD3细胞,腹水,抗肿瘤
【摘要】 目的 观察奥沙利铂对胃癌OCUM-2MD3细胞体外的细胞毒活性,以及对胃癌腹膜移植模型的体内抗肿瘤作用。方法 与顺铂(CDDP)比较,用MTT法和药效学体内实验法分别观察奥沙利铂对胃癌OCUM-2MD3细胞的体外细胞毒活性及对胃癌腹膜移植裸鼠的体内抗肿瘤作用。结果 体外实验证明,与CDDP相比,奥沙利铂对人对胃癌OCUM-2MD3细胞的体外细胞毒活性均明显增加(P<0.01),其两者IC 50 值相比较,L-OHP IC 50 关键词 胃癌 奥沙利铂 OCUM-2MD3细胞 腹水 抗肿瘤
Experimental study on anti-tumor effect of L-OHP in vivo
and vitro on gastric carcinoma cell lines OCUM-2MD3
Wang Lili,Zhao Qun,Li Yong,et al.
Department of Surgery,The Fourth Hospital of Hebei Medical University,Shijiazhuang050011.
【Abstract】 Objective To investigate the cytotoxicity of L-OHP in vitro,and its anti-tumor effect on OCUM-2MD3bearing nude mice in vivo.Methods The cytotoxicity in vitro byMTT assays and the anti-tumor efˉfect on OCUM-2MD3bearing naked mice in vivo by pharmacodynamic methods of L-OHP were tested respectively.Results L-OHP cells possessed a higher antitumor cytotoxic activity on OCUM-2MD3cells in vitro than cisplatin(CDDP);Three groups of naked mice treated with L-OHP were cured(at doses of9mg/kg~2.25mg/kg ......
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