【摘要】 目的 评价他汀类药物(Statins)对骨质疏松症的治疗作用。方法 106例原发性骨质疏松症患者，随机分成试验组和对照组:试验组(58例)口服辛伐他汀(simvastain)20mg+元素钙600mg，每日1次。钙剂组(48例)口服元素钙600mg，每日1次。两组疗程均为100天。治疗前后分别进行血清钙(Ca)、碱性磷酸酶(ALP)、骨钙素(OC)、尿肌酐(Cr)、尿羟脯氨酸(HOP)、双能X线骨密度(DEXA)测定和胸腰椎正、侧位X线片并进行比较。结果 治疗100天后，试验组56例、钙剂组46例获随访。试验组:与治疗前比较，除血清Ca治疗前后无明显变化(P>0.05)外，血ALP和血OC用药后均较用药前明显增加(P<0.01)，尿HOP/Cr比值用药后较用前显著减少(P<0.05)。对照组:血清Ca、ALP、OC和尿HOP/Cr治疗前后无明显变化(P>0.05)。试验组治疗100天后腰椎和股骨干BMD明显提高(P<0.05);钙剂组治疗100天后腰椎和股骨BMD均较治疗前明显下降(P<0.05)。结论 他汀类药物具有良好的治疗骨质疏松症作用，不但可以有效地缓解骨痛，还能激活成骨细胞、促进新骨形成、降低骨质疏松症的发病率。

    关键词 辛伐他汀 骨质疏松症 新骨形成

    Effect of Statins on the treatment about osteoporosis

    Yang Jianhui，Chen Wulan，Cheng Hu，et al.

    Department of Pain，First Hospital of Xi’an Jiaotong University，Xi’an710061.

    【Abstract】 Objective To study the effects of simvastain on osteoporosis.Methods 106patients with osteoˉporosis were randomly divided into experimental group and control group.Patients of experimental group had received simvastain(20mg/d)and calcium(600mg/d)by taking orally for100days.Patients in another group had received calcium(600mg/d)for100days.The determination markers included serum-calcium ......