【摘要】 目的 观察肝癌肝动脉置泵化疗及外周静脉化疗对机体免疫功能的影响。 方法 41例肝癌患者按化疗方法不同分为两组:肝癌切除的患者术中肝动脉置泵，术后2周化疗或未切除肝癌用腹腔镜经网膜右动脉或胃右动脉插管肝动脉置泵化疗(泵化组，n=20)，未手术者行外周静脉化疗(静化组，n=21)两组均在化疗前及化疗后1～3d内抽外周静脉血检查T淋巴细胞亚群及免疫球蛋白含量，另设对照组(n=18)，做相同检查。 结果 静化组化疗后的CD3、CD4、CD4/CD8比值及IgG、IgA、IgM的含量均明显低于化疗前(P<0.05，P<0.01)，并明显低于泵化组化疗后，P<0.05;而泵化组化疗前后CD3、CD4、CD8、CD4/CD8及IgG、IgA IgM含量比较差异无显著性(P>0.05)。 结论 肝癌肝动脉置泵化疗较外周静脉化疗对机体的免疫功能影响小。

    关键词 肝癌 化疗 T淋巴细胞亚群 免疫球蛋白

    Comparision of chang of T-lymophocyte subsets and immunoglobulin in liver carcinoma patients with liver intra-artery implantation pump chemotherapy and peripheral venous chemotherapy

    Li Debang，Chen Hao，Xue Zuoliang

    Dept.of General Surgery，the1st Hospital Affiliated Lanzhou Medical College，Lanzhou73000.

    【Abstract】 Objective To observe the influence on immune function of liver cancer patients by regional liver intra-Artery implantation pump chemotherapy(RAIPC)and peripheral venous chemotherapy(PVC).Methods Forty-one hepatic cancer patients weredivided into two groups.one(twenty-one patients)who were implanted tube into hepatic artery during operation or into gastric right artery by laparoscopy accepted regional intra-artery implanta-tion pump chemotherapy two weeks after radical operation ......