【摘要】 目的 观察慢性重型肝炎(慢重肝)患者血清IL-4、IL-18的变化，分析他们与慢重肝发病转归的关系。方法 采用双抗体夹心ELISA法测定血清IL-4、IL-18。结果 慢性肝炎组、慢重肝组IL-4、IL-18显著高于对照组(t=2.23，8.55;20.21，5.66，P=0.029，<0.001;<0.001;<0.001);慢重肝组IL-4、IL-18显著高于慢性肝炎组(t=19.43，3.84;P均<0.001);慢重肝存活组与死亡组血清IL-4、IL-18差异有显著性(t=2.03，4.24;P=0.04，<0.001);慢重肝组、慢性肝炎组IL-4与IL-18均呈正相关(r=0.6，0.51;P<0.01，P=0.019)。结论 IL-4、IL-18共同参与了慢重肝的发病，它们之间相互调节制约，影响着慢重肝的转归。

    关键词 慢性重型乙型肝炎 白细胞介素-4 白细胞介素-18

    Interleukin4and interleukin18levels in serums from patients with chronic severe hepatitis B

    Huang Lihua，Jiang Yueming，Yu Ping，et al.

    Wuxi Hospital for Infectious Disease，Jiangsu214007.

    【Abstract】 Objective To explore the interleukin4(IL-4)and interleukin18(IL-18)expression and relaˉtionship with chronic severe hepatitis B.Methods The levels of IL-4and IL-18in serum from45patients with chronic severe hepatitis B and35patients with chronic hepatitis B were measured by ELISA method.Results IL-4and IL-18were higher in chronic severe hepatitis B group and chronic hepatitis B group than in the control group(t=2.23 ......