【摘要】 目的 了解解脲支原体(UU)感染与抗磷脂抗体的相关性。 方法 对在中南大学湘雅二医院产科和中国建筑第五工程局中心医院妇产科就诊150例孕妇进行前瞻性的研究，应用免疫金标渗滤法，检测血清抗解脲支原体抗体(UU-Ab-IgG)和抗磷脂抗体(aPL IgA、IgG、IgM)。 结果 150例中aPL阳性75例，UU-Ab-IgG阳性49例;UU-Ab-IgG阳性组aPL阳性3l例，占63.27%;UU-Ab-IgG阴性组aPL阳性44例，占43.56%，差异有显著性(χ 2 =5.22，P=0.025<0.05)。双阳性者不良孕产史的发病率达64.52%。 结论 UU-Ab-IgG阳性和aPL阳性两者之间存在相关性，有协同作用，UU感染可能通过刺激机体免疫系统产生aPL，经抗磷脂抗体(aPL)途径，导致自然流产、死胎、早产、宫内发育迟缓等不良妊娠结局。

    关键词 解脲支原体 抗磷脂抗体 不良妊娠

    Antiphospholipid antibodies may be the possible pathway that ureaplasma urealyticum infection affects the pregnancy outcomes

    Zhu Liping，Zhu Fufan，Ding Hong

    The Center Hospital of CCFEB，Changsha410004.

    【Abstract】 Objective The purpose of the present study was to determine the correlation between Ureaplasma urealyticum infection and antiphospholipid antibodies.Methods Serum samples were taken from a prospective cohort of150pregnancy Xiangya Hospital of Central SouthUniversity and the Center Hospital of CCFEB.Serum antibodies to Ureaplasma urealyticum and cardiolipin were measured by a specific enzyme linked immunoadsorbent assay.Results There were75positive cases of anticardiolipin antibodies and49positive cases of anti-U ......