【摘要】 目的 探讨过氧化物酶体增殖物激活受体α(PPARα)基因第5外显子L162V(CCT→GTT)多态性与胰岛素抵抗综合征(IRS)的相关关系。方法 采用多聚酶联反应-限制性片段长度多态性(PCR-RFLP)的方法对湖北地区160例IRS患者及80例正常对照者PPARα基因L162V多态性进行研究。结果 在IRS患者和正常对照者中未发现PPARα基因L162V变异。结论 PPARα基因L162V多态性与本研究中国人IRS不相关。

    关键词 PPARα基因 多态性 胰岛素抵抗综合征

    Study on the relationship between peroxisome proliferator-activated

    receptorα(PPARα)gene polymorphism with insulin resistance syndrome

    Zhang Yin，Lei Hong，Deng Youping

    Department of Endocrinology，Zhongnan Hospital，Wuhan University，Wuhan430071.

    【Abstract】 Objective To investigate the peroxisome proliferator-activated receptorα(PPARα)gene L162V(CTT→GTT)polymorphism and its relationship with the risk of insulin resistance syndrome(IRS).Methods The genotype and allele frequency of PPARαgene L162V polymorphism was assayed by polymerase chain reaction(PCR)-restriction fragment length polymorphism(RFLP)between160IRS and80controls in Hubei.Results Both in IRS group and control group ......