【摘要】 目的 观察术后吗啡静脉镇痛伍用小剂量纳洛酮对减少手术后静脉吗啡镇痛有关的副作用发生率的作用和纳洛酮的合适剂量以及与吗啡的比例。方法 随机选择90例ASAⅠ～Ⅱ级的病人进行临床观察。所有病人均采用全身麻醉，术后接受吗啡静脉镇痛。对照组(A组)常规吗啡镇痛组;观察组(B组)伍用纳洛酮与吗啡的比例为1:100;C组纳洛酮与吗啡的比例为1:50。结果 在术后48h内对照组病人的恶心呕吐的发生率为26.67%，观察组病人的恶心呕吐发生率B组为6.7%，C组为3.3%;镇痛效果VRS值A组为0.87±0.89，B组为0.93±0.91，C组为0.94±0.92;皮肤瘙痒及皮疹发生率A组为16.67%，B组6.67%，C组6.67%。结论 静脉吗啡术后镇痛中伍用小剂量纳洛酮不降低吗啡的镇痛效能;纳洛酮可减少吗啡镇痛引起的恶心呕吐及皮肤瘙痒的发生率。

    关键词 吗啡 纳洛酮 静脉镇痛 副作用

    A clinical research on PCIA by morphine with Low-dose Naloxone

    Shi Yanpin，Peng Lichao

    Department of Anaesthesia，the Affiliated Fifth People’s

    Hospital of FudanUniversity，Shanghai，200240.

    【Abstract】 Objective To observe the effect on decreasing the side-effectrate using morphine together with low-dose naloxone for PCIA，and find out the proper dosage of naloxone and its proportion to morphine.Methods 90random selected ASAⅠ-Ⅱpatients for the clinical observation.All the patients were in generalanaesthesia and PCIA with morphine.The control group(group A)was treated by general morphine ......