【摘要】 目的 研究年龄、性别和性激素含量与血浆淀粉样蛋白P成分(Serum amyloid P-component，SAP)的关系。方法 用凝胶过滤法等纯化大白鼠血浆中SAP，制作抗SAP的抗体。分别皮下注射estradiol(E2)0.5mg、testosterone(T)25mg和40mg、以及醋酸脱氢表雄酮(DHEA)3.5mg，连续采血到第8天后测量血浆中SAP。结果 (1)两性大白鼠血中SAP浓度随年龄增加而增加。(2)SAP具有性别差异，雌性明显高于雄性(P<0.001)。(3)血中SAP的浓度因E2的投与而增加，投与T则无明显改变，而投与DHEA则可降低。结论 大白鼠血中SAP浓度随年龄增加而增加。雌性鼠的SAP浓度高于雄性鼠。E2可以使SAP增加，DHEA使其降低，而T则对其无影响。

    关键词 血清淀粉样蛋白P成分 女性蛋白 大白鼠 雌激素

    Effect of sex steroids on serum amyloid

    P-component in rats Dong Yuzhen，

    Jiang Aying，Gao Hong，et al.

    Departrment of Obstetrics and Gryneocology，

    No202Hospital of People’s Liberation Army，Shenyang110003.

    【Abstract】 Objective To investigate the relationship among age，sex and sexual hormone with level of Serum amyloid P-component(SAP).Methods Using gel filtration and affinity chromatography to purified the SAP of rat，and the anti-SAP was raised through the immunization of rabbits with the rat SAP.The rats were injected with estraˉdiol(E2) ......