【摘要】 目的 探讨慢性阻塞性肺疾病(COPD)患者凝血三项检测的临床意义及与血气分析的相关性。方法 对30例COPD患者治疗前后凝血三项、血气分析及30例对照组的凝血三项分别进行测定。 结果 血浆纤维蛋白原(FIB)、部分活化凝血活酶时间(APTT)在COPD加重期患者明显增高，与对照组相比有显著性差异。血浆FIB、APTT与血氧分压(PaO 2 )呈负相关，而与血二氧化碳分压(PaCO 2 )呈正相关。 结论 COPD患者存在凝血功能的异常，抗凝药物治疗可能对COPD患者的病情改善有益。

    关键词 慢性阻塞性肺疾病 凝血三项 血气分析

    The correlative study of blood gas analysis and three coagulation markers detection in patients with chronic obstructive pulmonary disease

    Jiang Zhenghua，Lv Yuanwen，Zhu Muyun，et al.

    Department of Respiratory Medicine，Subei People's Hospital，Yangzhou225001.

    【Abstract】 Objective To study the clinical significance of three coagulation markers detection and the rela-tionship with blood gas analysis in patients with chronic obstructive pulmonary disease.Methods The coagulation pa-rameters was determined in30patients with chronic obstructive pulmonary disease and in30controls respectively.Blood gas analysis was measured in30patients with COPD.Results The plasma fibrinogen(FIB)level and active partial thromboplastin time(APTT)was significantly higher in exacerbated patients than in controls(P<0.05).The plasma FIB and APTT were negativly correlated with PaO 2 .The plasma FIB was positively correlated with PaCO 2 .Conclusion The COPD patients have abnormal coagulation state ......