【摘要】 目的 探索临床针刺加当归芍药散(DGSYS)治疗阿尔采默氏症的可能机理。 方法 通过腹腔注射药物东莨菪碱或亚硝酸钠，或者用奎宁酸损毁大脑海马CA 1 区诱发大鼠发生记忆力障碍，造成不同类型的大鼠“痴呆”模型，对照性观察针刺、针刺加DGSYS、DGSYS及NM对记忆障碍功能的影响和与记忆相关实验指标参数的变化。 结果 针刺加DGSYS疗法抗痴呆作用机制可能与调节大脑兴奋性氨基酸Glu能和胆碱能神经递质的功能，改善体内抗氧化系统的能力，如改善超氧化物歧化酶/脂质过氧化物含量及一氧化氮/一氧化氮合酶的活性比值有关，它们的协调作用促使了大脑及海马CA 1 区受损的痴呆模型的LTP增强、大鼠学习记忆能力的复苏，从而改善了痴呆症状。 结论 针刺加DGSYS疗法治疗AD痴呆及改善学习记忆能力的作用具有确切的科学依据，值得临床推广应用。

    【关键词】 针灸 当归芍药散 阿尔茨海默症 痴呆造模 神经递质 抗氧化作用 长时程增强

    The studies on mechanism of Alzheimer's disease by the acupuncture treatment combined with Danggui Shaoyao San of TCM

    Li Zhongren，Shen Meihong，Mu Yanyun，et al.

    Nanjing University of TCM，Jiangsu210029.

    【Abstract】 Objective To explore into the probable mechanism of Alzheimer's disease(AD)by the acupuncture treatment combined with DGSYS of TCM.Methods Three kinds of model rats with dysmnesia which were made by injected into drug of scopolamine or NaNo 2 in the abdomen separately and injured at the hippocampal CA 1 in brian by drug of quinolinic acid treated by single acupuncture or acupuncture combined with DGSYS of TCM or DGSYS of TCM were observed separately ......