【摘要】 目的 观察妊娠早期妇女口服叶酸及维生素B 12 对同型半胱氨酸(Hcy)的影响。 方法 选择妊娠早期妇女276例，随机分为两组:(1)对照组(128例):不服用叶酸等任何影响血浆Hcy的药物。(2)叶酸+维生素B 12 组(148例):每天服用5mg叶酸及0.5mg维生素B 12 。服药前及服药后3个月查血浆Hcy及叶酸水平。 结果 叶酸+维生素B 12 组服药后血浆Hcy水平与未服药组血浆Hcy水平相比差异均有显著性(t=2.55，P<0.05)。 结论 妊娠早期妇女每天服用叶酸5mg+维生素B 12 可以降低空腹血浆Hcy水平，可以降低妊高征的发病率。

    关键词 妊娠早期 叶酸 维生素B 12 妊高征 同型半胱氨酸

    Effects of folic acid and Vitamin B 12 on pregnancy induced hypertension in early pregnancy

    Wang Jurong，Han Xinyan，Cheng Yanmei

    Department of Gynecology，Handan Central Hospital，Handan056001.

    【Abstract】 Objective To investigate the effect of folic acid and vitamin B 12 in fasting plasma homocysteine(Hcy)concentration in pregnancy induced hypertension.Methods Two hundreds and seventy-six the first-trimester pregnant women were randomly divided into two groups.The patients in Group1were not received folic acid and vitamin B 12 as the control group;the patients in Group2were given with5mg of folic acid and0.5mg of vitamin B 12 for3months as the study group.Fasting plasma Hcy concentration were measured before and after the treatment in the two groups.Results The plasma Hcy levels of post-treatment in Group2were significantly lower compared with Hcy levels of Group1(t=2.55 ......