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缺氧预适应兔不同组织提取液对小鼠缺氧耐受性的影响
http://www.100md.com 《中华实用医药杂志》 2005年第7期
缺氧,缺氧,预适应,耐受,1材料与方法,2结果,3讨论,参考文献
     【摘要】 目的 观察缺氧预适应兔不同组织提取液对小鼠缺氧耐受的影响。 方法 利用急性重复缺氧模型,在常压低氧、低压低氧条件下分别观察给予缺氧预适应兔不同组织提取液后小鼠缺氧耐受的变化。 结果 给予缺氧预适应兔肝匀浆提取液可使小鼠的缺氧耐受时间由对照组(16.7±2.1)min显著增加到(25.5±6.6)min(P<0.05)。而且缺氧预适应兔肝匀浆提取液使小鼠在低压低氧条件下30min内存活率由对照组的(12.5±1.1)%明显提高到(84.5±4.6)%(P<0.05)。 结论 缺氧预适应兔体内尤其是肝脏内可能产生了抗缺氧的物质,从而提高了小鼠对低氧的耐受性。

    【关键词】 缺氧 预适应 耐受

    The effect of different organic homogenate taken from hypoxic preconditioning rabbits on the mice'tolerance to pypoxia

    Zhang Bo,Guo Wenyi,Li Zhichao,et al.

    Department of Pathophysiology,Fourth Military Medical University,Xi'an,Shanxi710032.

    【Abstract】 Objective To study the effects of different organic homogenate taken from hypoxic precondition-ing rabbits on the mice's tolerance to hypoxia.Methods The hypoxic preconditioning rabbits were gotten by the model of repetitive hypoxia.The change of mice'tolerance to hypoxia was observed after treated with different organic homogenate taken from hypoxic preconditioning rabbits under normal atmospheric pressure and hypoxia circumstance ......

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