【摘要】 目的 探讨凝血酶与大鼠脑出血后脑水肿的关系。 方法 以SD大鼠为研究对象，随机将大鼠分为生理盐水组、脑出血组、凝血酶组。以自体血、凝血酶注入大鼠尾状核，建立脑出血模型，采用干湿重法观察脑水肿情况。每组每时相(4h，12h，24h，48h，72h，7d)各6只大鼠。 结果 脑出血和凝血酶组脑含水量与生理盐水组在4h，12h，24h，48h，72h比P<0.05，而7天这个时相点各组间无明显差异(P>0.05)。脑出血与凝血酶组脑含水量各时相间无明显差异(P>0.05)。 结论 大鼠脑出血后可早期(4h)引起明显脑水肿，其高峰时间为24～48h，3天后脑水肿开始消退，7天后逐渐趋于正常，其中凝血酶在脑水肿中起关键作用。

    【关键词】 脑出血 凝血酶 脑水肿 大鼠

    The mechanism of thrombin in brain edema after intracerebral hemorrhage

    Zheng Juan，Cui Guiyun，Shi Hongjuan，et al.

    Department of Neurology，Affiliated Hospital of Xuzhou Medical College，Xuzhou，Jiangsu221002.

    【Abstract】 Objective To investigate the effect of thrombin on brain edema.Methods Rats were divided randomly into saline group，intracerebral hemorrhage group，trombin group.We had respectively injected autologous blood50μl and thrombin5U into the right caudate nucleuses in rats to make two different kinds of animal model.Brain edema was observed using a”dry-wet weighing technique”.Each group and each time(4h ......