【摘要】 严重急性呼吸综合征是由一种新型冠状病毒(SARS-CoV)引起，SARS-CoV包括4种结构蛋白:S蛋白，E蛋白，M蛋白和N蛋白。S蛋白不仅在受体结合和病毒融合中起重要作用，而且是诱导保护性抗体的主要抗原。ACE2和CD209L已被证实是SARS-CoV的2个受体，SARS-CoV入侵细胞依赖于S蛋白与受体的相互作用.对其机制的探讨将有助于病毒抑制剂和疫苗的研制。

    【关键词】 严重急性呼吸综合征 S蛋白 受体 融合

    【Abstract】 Severe Acute Respiratory Syndrome(SARS)is caused by a newly identified coronavirus(SARS-CoV).The SARS-CoV has four structural proteins:spike glycoprotein，envelope protein，membrane protein and nu-cleocapsid protein.The SARS-CoV S glycoprotein is not only responsible for receptor binding and virus fusion，but also a major antigen among the SARS-CoV proteins that induces protective antibody responses.ACE2and CD209L were identified as receptors for SARS-CoV.Cellular entry of SARS-CoV is dependent on interaction between SARS-CoV S glycoprotein and its receptor.The mechanismwill likely contribute to the development of entry inhibitors and vaccines.

    【Key words】 SARS-CoV spike protein receptor fusion

    严重急性呼吸综合征(severe acute respiratory syndrome，SARS)的暴发和流行，对人类的健康造成了极大的威胁。因此SARS的研究显得尤为紧迫和重要。其致病体为SARS冠状病毒(SARS-CoV)已得到确定，并随后完成了其基因组测序 [1] 。SARS为RNA正链病毒 ......