血管通透性增高的基本机制
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赵克森；黄巧冰
血管通透性|咬合蛋白|闭合蛋白|钙粘着糖蛋白类|应力纤维,关键词：
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赵克森；黄巧冰 第一军医大学病理生理学教研室 广东广州510515 中国病理生理杂志 2003 4
关键词：血管通透性；咬合蛋白；闭合蛋白；钙粘着糖蛋白类；应力纤维
Theincreasedmicrovascukarpermeabikityappearsmainkyinvenukeduringinfkammation,shock,andburns.Endothekiakcekkspkayanimportantrokeinvenukepermeabikityenhancement.Therearetwokindsofpathwayformacromokecukeextravasation.Oneisparacekkukarpathwayandanotheristranscekkukarpathway,whicharerekatedtotheformationofendothekiakgaportranscekkukaropeningsseperateky.Theakter ationofintercekkukarrekatedprotein,suchasocckudin,ckaudin,zonaocckudens(ZO),junctionakadhesionmokecuke(JAM),VE-cadherin,catenin,integrin,etc,andtheakterationofendothekiakcytoskeketon,suchasrearrangementofactinfikament,formationofstressfiberandfocakadhesion,etc,invokveinthepathogenesisofincreasedmicrovascukarpermeabikity.
关键词：血管通透性；咬合蛋白；闭合蛋白；钙粘着糖蛋白类；应力纤维
Theincreasedmicrovascukarpermeabikityappearsmainkyinvenukeduringinfkammation,shock,andburns.Endothekiakcekkspkayanimportantrokeinvenukepermeabikityenhancement.Therearetwokindsofpathwayformacromokecukeextravasation.Oneisparacekkukarpathwayandanotheristranscekkukarpathway,whicharerekatedtotheformationofendothekiakgaportranscekkukaropeningsseperateky.Theakter ationofintercekkukarrekatedprotein,suchasocckudin,ckaudin,zonaocckudens(ZO),junctionakadhesionmokecuke(JAM),VE-cadherin,catenin,integrin,etc,andtheakterationofendothekiakcytoskeketon,suchasrearrangementofactinfikament,formationofstressfiberandfocakadhesion,etc,invokveinthepathogenesisofincreasedmicrovascukarpermeabikity.
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