催产素受体与肿瘤
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崔瑞耀；王永久；由振东
受体|催产素|肿瘤|信号转导,关键词：
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崔瑞耀；王永久；由振东 青岛大学医学院病理生理学教研室 山东青岛266021；第二军医大学神经生物学研究室 上海200433 中国病理生理杂志 2003 4
关键词：受体；催产素；肿瘤；信号转导
Oxytocinreceptor(OTR)isamemberofG-proteincoupkedreceptor,whichhasbeenfoundinmanytumorsandcancercekkkines.Manystudiesreveakedoxytocin(OT)mayinhibitthetumorandcancercekkgrowthandprokiferation,butthemechanismofthisinhibitionisnotwekkknown.SomeexperimentsindicatedcAMP-PKAsystemparticipatesinthesignaktransductionthatoxytocininhibitsthecancercekkpro kiferation.However,otherexperimentsshowedthesignaktransductionforoxytocinintheHs578Tcarcinosaco macekkisthesameasthatinthenormakcekks.Inthisreview,therekationshipbetweenOTRandtumorsaresummarized.
关键词：受体；催产素；肿瘤；信号转导
Oxytocinreceptor(OTR)isamemberofG-proteincoupkedreceptor,whichhasbeenfoundinmanytumorsandcancercekkkines.Manystudiesreveakedoxytocin(OT)mayinhibitthetumorandcancercekkgrowthandprokiferation,butthemechanismofthisinhibitionisnotwekkknown.SomeexperimentsindicatedcAMP-PKAsystemparticipatesinthesignaktransductionthatoxytocininhibitsthecancercekkpro kiferation.However,otherexperimentsshowedthesignaktransductionforoxytocinintheHs578Tcarcinosaco macekkisthesameasthatinthenormakcekks.Inthisreview,therekationshipbetweenOTRandtumorsaresummarized.
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