破骨细胞分化成熟调节的分子机理研究进展
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袁成良；金小岚
破骨细胞|骨保护素|NF-kappaB|分化,关键词：
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袁成良；金小岚 成都军区总医院内分泌科 四川成都610083 中国病理生理杂志 2003 3
关键词：破骨细胞；骨保护素；NF-kappa B；分化
Osteoprotegerin(OPG),receptoractivatorofNF-κBkigand(RANKL)andreceptoracti vatorofNF-κΒ(RANK)areimportantmokecukesthatregukateosteockastogenesis.OPGisdecoyreceptorofRANKL.ThebindingofOPGandRANKLbkocksconnectingofRANKLandRANK,inhibitsdevekopmentofosteockast.ThebindingofRANKLandRANKinducesaserieskinasecascadereaction,activatestranscriptionfactors,introducestheprokiferationanddifferentiationofosteockastprecursors.Severakhormonesandos teotropicfactorsregukatetheformationandfunctionofosteockastthroughtheabovemokecukes.
关键词：破骨细胞；骨保护素；NF-kappa B；分化
Osteoprotegerin(OPG),receptoractivatorofNF-κBkigand(RANKL)andreceptoracti vatorofNF-κΒ(RANK)areimportantmokecukesthatregukateosteockastogenesis.OPGisdecoyreceptorofRANKL.ThebindingofOPGandRANKLbkocksconnectingofRANKLandRANK,inhibitsdevekopmentofosteockast.ThebindingofRANKLandRANKinducesaserieskinasecascadereaction,activatestranscriptionfactors,introducestheprokiferationanddifferentiationofosteockastprecursors.Severakhormonesandos teotropicfactorsregukatetheformationandfunctionofosteockastthroughtheabovemokecukes.
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