关键词:哮喘;血液;神经肽A
提要 目的和方法 :采用放免分析方法测定26例支气管哮喘患者急性发作时及发作缓解后血液中神经肽A(NKA)含量,并与健康人进行对比。结果:哮喘发作时患者血中NKA含量明显高于对照组,缓解后与对照组无显著性差异。结论:NKA参与哮喘发作的病理生理过程,可能是哮喘发作的因素之一。
Alteration in neurokinin A in the circulating blood
in bronchial asthmatic patients
Liu Xiaohong, et al
Abstract Aim and Method : Theconcentration of neuokinin A(NKA) in the circulating blood in 26 bronchial asthma patientswas measured using radioimmunoassay. Results: In asthma, the NKA level in the blood of thebronchial asthma patients was much higher than that of the normal controls (P <0.005).The next morning after the asthma ceased, there was no clear alteration in the NKA levelin the blood of the patients compared with the control (P >0.05). Conclusion: TheNKA may play an important role in the pathogenesis of asthma. It may provide at heoreticalbasis for the treatmant of asthma with NKA antagonist or inhibitor of NKA receptor.
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