徐绍勤 欧阳林 曾省三 李凡成 谭奕 彭斌 徐绍勤 曾省三 李凡成 谭奕 彭斌 湖南中医学院附二院耳鼻喉科，湖南长沙410005；欧阳林 湖南省179医院，湖南长沙410007 中药新药与临床药理 1999 0 10 6


    关键词：复聪片；药理学；聋，感音神经性；中药疗法；庆大霉素；中毒；耳；豚鼠 期刊 zyxyylcyl 0 药效与毒理学研究 fur -->


    

摘要：对庆大霉素(GM)致豚鼠的耳毒性反应进行拮抗及治疗研究。证实复聪片可减轻GM的耳毒性反应，保护耳蜗听毛细胞，拮抗GM所致之听阈升高，电镜观察显示毛细胞损害减轻。对已由GM致聋的豚鼠，复聪片可促使受损毛细胞形态及功能在一定程度上恢复，有效降低GM耳中毒豚鼠听阈，阻止GM停药后迟发的听阈升高。表明复聪片对GM所致的豚鼠耳中毒有一定的防治作用。

    中图分类号：R285.5；R764.431 文献标识码：A 文章编号：1003-9783(1999)06-0341-03

Effects of Fucong Tablet on Gentamycin-Induced Ototoxicosis in Guinea Pigs

XU Shao-qin,OU Yang-lin,ZENG Sheng-san,et al

    (The Second Affiliated Hospital of Hunan College of TCM, Changsha 410005)

Abstract :The therapeutic effects of Fucong Tablet against gentamycin (GM)-induced ototoxicosis in guinea pigs were presented in this paper. The results indicated that Fucong Tablet could decrease the ototoxic reaction of GM, protect auditory hair cells of cochleae and reduce the elevation of the auditory threshold. As for the GM-induced deafness in guinea pigs, Fucong Tablet could restore the structure and function of the damaged hair cells to some extents, effectively lower the auditory threshold and counteract the delayed elevation of the auditory threshold occurred after GM administration. It is revealed that Fucong Tablet has a certain preventive and curative effect on the ototoxic reaction induced by GM.

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