LAK细胞_IL-2_慢性乙型肝炎

异体LAK细胞联合IL-2治疗慢性乙型肝炎的近期疗效观察

http://www.100md.com 《广西预防医学》 1999年第4期

LAK细胞|IL-2|慢性乙型肝炎|肝功能,关键词：,ObservationontherapeuticeffectofcombinedallogeneticLAKcellandIL-2onpatientswithchronichepatitisBvirusinfection.,Abstract,Keywords,1材料与方法,1.1,1.2,1.3,1.4,1.5,2结果

     袁海宁罗光汉吴继周广西医科大学第一附属医院(南宁530021) 广西预防医学 1999 0 5 4

    关键词：LAK细胞；IL-2；慢性乙型肝炎；肝功能期刊 gxyfyx 0 论著 fur -->

摘要 对73例慢性乙型肝炎患者随机分为两组，即异体LAK细胞联合IL-2治疗组48例和一般护肝药物对照组25例。在治疗前及治疗后一个月检测乙型肝炎病毒DNA，两对半血清HBV标志物、肝功能等项目。结果显示治疗组HBeAg阴转率为60.4%(P<0.01)，HBcAg、抗HBc-IgM及HBVDNA的阴转率分别为37.5%、29.2%和41.7%(P<0.05)。HBsAg阴转率为6.3%与对照组无显著性差异(P>0.05)。治疗组肝功能恢复效果较对照组佳。

Observation on therapeutic effect of combined allogenetic LAK cell and IL-2 on patients with chronic hepatitis B virus infection.

Yuan Haining,Luo Guanghan,Wu Jizhou. Department of Infectious Diseases,First Affiliated Hospital of Guangxi Medical University,Nanning 530021

Abstract Seventy-three cases of chronic hepatitis B virus infection were random divided into case and control groups to probe the changes of replication marks of hepatitis B virus in patients treated by combined allogenetic LAK cell and IL-2. HBVDNA,other serum marks of HBV and liver function in the patients were tested before and one month after treatment.The results showed that the negative seroconversion rates of HBeAg,HBcAg,anti-HBc-IgM and HBVDNA were 60.4%,37.5%,29.2%and 37.5%,respectively (P<0.05).The study also demonstrated that there was a faster and better in recovery of liver function in case group than control one.

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